WYC-209

Product Name: WYC-209
CAS No.: 2131803-90-0
Chemical Name: WYC-209
Synonyms: WYC-209;Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate;Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate , WYC-209;Apoptosis,WYC-209,WYC 209,Retinoid X receptors,Inhibitor,Retinoic acid receptors,Autophagy,RAR/RXR,inhibit;5-Pyrimidinecarboxylic acid, 2-[2-(3,4-dihydro-4,4-dimethyl-1-oxido-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester
CBNumber: CB44888914
Molecular Formula: C20H20N2O3S
Formula Weight: 368.45
MOL File: 2131803-90-0.mol

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WYC-209 Property

storage temp.: Store at -20°C
solubility: DMSO : 83.33 mg/mL (226.16 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2402
Product name: WYC-209
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $95
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2402
Product name: WYC-209
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $227.5
Updated: 2025/07/31

ChemScene

Product number: CS-0084453
Product name: WYC-209
Purity: 99.64%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0009231
Product name: WYC-209
Purity: 95.00%
Packaging: 5MG
Price: $455.27
Updated: 2021/12/16

ChemScene

Product number: CS-0084453
Product name: WYC-209
Purity: 99.64%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

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WYC-209 Chemical Properties,Usage,Production

Uses

WYC-209 RAR Agonist is used in the preparation of the retinoid compounds and their application as anticancer agents.

Biological Activity

Synthetic retinoid with antiproliferative activity', 'WYC-209 is a synthetic retinoid with antiproliferative activity and better inhibition of cancer cell growth and proliferation than Tazarotene or ATRA (all-trans-retinoic acid). WYC-209 was shown to inhibit proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with an IC50 value of 190 nM and also inhibited proliferation of TRCs of human melanoma, lung cancer, ovarian cancer, and breast cancer in culture.

in vivo

WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases^[1].

Animal Model:	Female immune-competent C57BL/6 mice^[1]
Dosage:	0.022, 0.22?mg/kg
Administration:	Intravenous injection; once every two days for 25 days
Result:	Four out of eight mice formed lung metastases at dose of 0.022?mg?/kg, only one out of eight mice formed lung metastases at dose of 0.22?mg/kg.

WYC-209 Preparation Products And Raw materials

Raw materials

Preparation Products

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WYC-209 Suppliers

China 34 United States 4 Global 38

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2131803-90-0, WYC-209Related Search:

WYC-210

WYC-209

5-Pyrimidinecarboxylic acid, 2-[2-(3,4-dihydro-4,4-dimethyl-1-oxido-2H-1-benzothiopyran-6-yl)ethynyl]-, ethyl ester

Apoptosis,WYC-209,WYC 209,Retinoid X receptors,Inhibitor,Retinoic acid receptors,Autophagy,RAR/RXR,inhibit

Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate

Ethyl 2-((4,4-dimethyl-1-oxidothiochroman-6-yl)ethynyl)pyrimidine-5-carboxylate , WYC-209

2131803-90-0