ChemicalBook > CAS DataBase List > (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
- Product Name
- (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
- CAS No.
- 1832713-02-6
- Chemical Name
- (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid
- Synonyms
- RA 839;(3S)-1-[4-(2,3,5,6-tetramethylbenzenesulfonamido)naphthalen-1-yl]pyrrolidine-3-carboxylic acid;(S)-1-(4-((2,3,5,6-Tetramethylphenyl)sulfonamido)naphthalen-1-yl)pyrrolidine-3-carboxylic acid;(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid;3-Pyrrolidinecarboxylic acid, 1-[4-[[(2,3,5,6-tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-, (3S)-
- CBNumber
- CB44902533
- Molecular Formula
- C25H28N2O4S
- Formula Weight
- 452.57
- MOL File
- 1832713-02-6.mol
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(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid Property
- Boiling point:
- 707.9±70.0 °C(Predicted)
- Density
- 1.313±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C, protect from light
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 10.04±0.30(Predicted)
- color
- Pale Brown to Light Brown
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N-Bromosuccinimide Price
Tocris
- Product number
- 5707
- Product name
- RA839
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $236
- Updated
- 2021/12/16
Tocris
- Product number
- 5707
- Product name
- RA839
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $960
- Updated
- 2021/12/16
TRC
- Product number
- R729035
- Product name
- RA839
- Packaging
- 50mg
- Price
- $875
- Updated
- 2021/12/16
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(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid Chemical Properties,Usage,Production
Uses
RA 839 is a noncovalent small molecule binder to Keap1 and a selective activator of Nrf2 signaling.
Biological Activity
RA839 is an active in vivo, highly selective and potent activator of Nrf2 (transcription factor NF-E2-related factor 2) signaling. RA839 binds noncovalently to the Nrf2-interacting kelch domain of Keap1 thereby inhibiting the interaction between Keap1 and Nrf2. RA839 inhibits the induction of both inducible nitric oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA-839 is a potent antagonist of Rotavirus propagation in vitro th at inhibits viral RNA and protein expression.
storage
Store at +4°C
(3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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