ChemicalBook > CAS DataBase List > 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
- Product Name
- 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
- CAS No.
- 688347-51-5
- Chemical Name
- 4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
- Synonyms
- SPL 334;SPL-334 >=98% (HPLC);4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid;Benzoic acid, 4-[[2-[[(2-cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]-
- CBNumber
- CB44902735
- Molecular Formula
- C22H15N3O3S2
- Formula Weight
- 433.5
- MOL File
- 688347-51-5.mol
More
Less
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid Property
- Boiling point:
- 694.0±65.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 20mg/mL, clear
- pka
- 4.21±0.10(Predicted)
- form
- powder
- color
- white to beige
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- S681743
- Product name
- SPL334
- Packaging
- 50mg
- Price
- $820
- Updated
- 2021/12/16
More
Less
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid Chemical Properties,Usage,Production
Uses
SPL 334 is an S-Nitrosoglutathione Reductase inhibitor.
Biological Activity
SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR), the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO), which plays a critical role in nitric oxide signaling in the respiratory tract. In a mouse model of allergic airway inflammation, SPL-334 reduced airway hyperreactivity, and in a bleomycin injury model of interstitial lung disease, SPL-334 reduced lung inflammation and fibrosis. Studies for treatment of asthma, idiopathic pulmonary fibrosis (IPF), and inflammation are ongoing.
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less