ChemicalBook > CAS DataBase List > BAY-218

BAY-218

Product Name
BAY-218
CAS No.
2162982-11-6
Chemical Name
BAY-218
Synonyms
CPD3504;BAY-218;BAY-2335218;AHR antagonist 1;BAY-218, 10 mM in DMSO;BAY-218(AHR antagonist 1);BAY2335218;BAY-2335218;BAY 2335218;BAY218;BAY 218;BAY-218;6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(1S)-2-hydroxy-1-methyl-ethyl]-3-oxo-pyridazine-4-carboxamide;(S)-6-(4-Chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2，3-dihydropyridazine-4-carboxamide;6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-3-oxo-2,3-dihydropyridazine-4-carboxamide
CBNumber
CB44908494
Molecular Formula
C20H17ClFN3O3
Formula Weight
401.82
MOL File
2162982-11-6.mol
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BAY-218 Property

Density 
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:80.0(Max Conc. mg/mL);199.09(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);49.77(Max Conc. mM)
form 
Solid
pka
11.81±0.20(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0040922
Product name
AHRantagonist1
Purity
99.07%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-0040922
Product name
AHRantagonist1
Purity
99.07%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0040922
Product name
AHRantagonist1
Purity
99.07%
Packaging
25mg
Price
$290
Updated
2021/12/16
ChemScene
Product number
CS-0040922
Product name
AHRantagonist1
Purity
99.07%
Packaging
50mg
Price
$490
Updated
2021/12/16
ChemScene
Product number
CS-0040922
Product name
AHRantagonist1
Purity
99.07%
Packaging
100mg
Price
$850
Updated
2021/12/16
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BAY-218 Chemical Properties,Usage,Production

Uses

BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses[1].

in vivo

BAY-218 (example 23) (p.o; 30 mg/kg; bid) has good anti-tumor effect combinated with aPD-L1[1].

Animal Model:Balb/c mice (subcutaneously CT26 cells)[1]
Dosage:30 mg/kg
Administration:p.o, bid
Result:Significantly decreased tumors size combinated with aPD-L1.

References

[1] Norbert Schmees, et al. 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamides. WO2017202816A1.

BAY-218 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-218 Suppliers

China 70 United States 5 Global 75
Dalian Meilun Biotech Co., Ltd.
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2162982-11-6, BAY-218Related Search:


  • BAY2335218;BAY-2335218;BAY 2335218;BAY218;BAY 218;BAY-218
  • BAY-218
  • CPD3504
  • BAY-2335218
  • AHR antagonist 1
  • 4-Pyridazinecarboxamide, 6-(4-chlorophenyl)-2-(3-fluorophenyl)-2,3-dihydro-N-[(1S)-2-hydroxy-1-methylethyl]-3-oxo-
  • 6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(2S)-1-hydroxypropan-2-yl]-3-oxo-2,3-dihydropyridazine-4-carboxamide
  • (S)-6-(4-Chlorophenyl)-2-(3-fluorophenyl)-N-(1-hydroxypropan-2-yl)-3-oxo-2，3-dihydropyridazine-4-carboxamide
  • BAY-218(AHR antagonist 1)
  • cancer,human monocytic U937 cells,AHR antagonist1,inhibit,Aryl Hydrocarbon Receptor,Inhibitor,BAY218,aryl hydrocarbon receptor (AHR),U87 glioblastoma cells,AHR antagonist-1,immune,BAY 218,BAY-218,AhR
  • 6-(4-chlorophenyl)-2-(3-fluorophenyl)-N-[(1S)-2-hydroxy-1-methyl-ethyl]-3-oxo-pyridazine-4-carboxamide
  • BAY-218, 10 mM in DMSO
  • 2162982-11-6