ChemicalBook > CAS DataBase List > BAY-598 R-isomer
BAY-598 R-isomer
- Product Name
- BAY-598 R-isomer
- CAS No.
- 1906920-28-2
- Chemical Name
- BAY-598 R-isomer
- Synonyms
- (R)-BAY-598;BAY-598 R-isomer;BAY598 Risomer,BAY 598 R isomer;N-[(4R)-1-[(cyanoamino)[[3-(difluoromethoxy)phenyl]imino]methyl]-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxy-acetamide;Acetamide, N-[(4R)-1-[(cyanoamino)[[3-(difluoromethoxy)phenyl]imino]methyl]-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxy-
- CBNumber
- CB44920777
- Molecular Formula
- C22H20Cl2F2N6O3
- Formula Weight
- 525.34
- MOL File
- 1906920-28-2.mol
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BAY-598 R-isomer Property
- Boiling point:
- 663.5±65.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 13.34±0.10(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 29174
- Product name
- (R)-BAY-598
- Packaging
- 1mg
- Price
- $65
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29174
- Product name
- (R)-BAY-598
- Packaging
- 10mg
- Price
- $494
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29174
- Product name
- (R)-BAY-598
- Packaging
- 500μg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 29174
- Product name
- (R)-BAY-598
- Packaging
- 5mg
- Price
- $266
- Updated
- 2024/03/01
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BAY-598 R-isomer Chemical Properties,Usage,Production
Description
BAY-598 R-isomer is the R-isomer of BAY589. BAY-598 R-isomer may be used as a reference compound. BAY-598 is a potent, peptide-competitive chemical probe for SMYD2. BAY-598 has a unique chemotype relative to the current SMYD2 chemical probe LLY-507. BAY-598 inhibits in vitro methylation of p53K370 with IC50 = 27 nM and has more than 100-fold selectivity over other histone methyltransferases and other non-epigenetic targets. BAY-598 inhibits the methylation of p53K370 in cells with IC50 < 1 μM. (Further to this, BAY-598 has properties that are compatible with in vivo experiments.) A control compound, BAY-369, has also been developed. BAY-369 inhibits the in vitro methylation of p53K370 with IC50 > 70 micromolar.
BAY-598 R-isomer Preparation Products And Raw materials
Raw materials
Preparation Products
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