ChemicalBook > CAS DataBase List > IAXO-102

IAXO-102

Product Name: IAXO-102
CAS No.: 1115270-63-7
Chemical Name: IAXO-102
Synonyms: IAXO-102;IAXO-102 ，S0002;IAXO-102 (CD14/TLR4 Antagonist) (synthetic);Methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-α-D-glucopyranoside;α-D-Glucopyranoside, methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-;IAXO102,IAXO 102,Toll-like Receptor (TLR),Inhibitor,IAXO-102,inhibit
CBNumber: CB44927534
Molecular Formula: C35H71NO5
Formula Weight: 585.96
MOL File: 1115270-63-7.mol

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IAXO-102 Property

Boiling point:: 650.2±55.0 °C(Predicted)
Density: 0.96±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Ethanol : 50 mg/mL (85.33 mM; Need ultrasonic)|DMSO : 5 mg/mL (8.53 mM; Need ultrasonic)
form: A solid
pka: 13.00±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Adipogen Life Sciences

Product number: IAX-600-002-M001
Product name: IAXO-102(CD14/TLR4Antagonist)(synthetic)
Purity: ≥98%(TLC)
Packaging: 1mg
Price: $223
Updated: 2021/12/16

ChemScene

Product number: CS-0089755
Product name: IAXO-102
Purity: >98.0%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0089755
Product name: IAXO-102
Purity: >98.0%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0089755
Product name: IAXO-102
Purity: >98.0%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0089755
Product name: IAXO-102
Purity: >98.0%
Packaging: 100mg
Price: $2650
Updated: 2021/12/16

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IAXO-102 Chemical Properties,Usage,Production

Uses

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development[1].

Biological Activity

IAXO-102 is a TLR4 antagonist targeting the MD-2 and CD14 co-receptors,which inhibits MAPK and p65 NF-κB phosphorylation and downregulates the expression of TLR4-dependent pro-inflammatory proteins. It inhibits the development of experimental abdominal aortic aneurysm (AAA).

in vitro

IAXO-102 (1-10 μM, for 2 hours) inhibits MAPK and p65 NF-κB phosphorylation in human umbilical vein endothelial (HUVEC) cells.
IAXO-102 (10 μM, for 17 hours) suppresses LPS induced proinflammatory proteins MCP-1 and IL-8 production in HUVEC.

Western Blot Analysis

Cell Line:	Human umbilical vein endothelial (HUVEC) cells
Concentration:	1-10 μM
Incubation Time:	Pretreatment for 1 hour and then exposed to LPS (100 ng/mL) for additional 1 hour
Result:	Significantly inhibited LPS- stimulated MAPK/p65nF-ΚB phosphorylation.

in vivo

IAXO-102 (3 mg/kg/day, sc for 28 days) significantly retards Angiotensin II induced increase in aortic diameter in mice.

Animal Model: < /td>	Six-monthold ApoE ^?/? /C57Bl6
Dosage:	3 mg/kg/day
Administration:	SC for 28 days
Result:	Significantly retarded Angiotensin II -induced increase in aortic diameter.

target

Target	Value
TLR4 ()
MAPK ()
NF-κB ()

IC 50

TLR4

References

[1] Huggins C, et al. A novel small molecule TLR4 antagonist (IAXO-102) negatively regulates non-hematopoietic toll like receptor 4 signalling and inhibits aortic aneurysms development. Atherosclerosis. 2015 Oct;242(2):563-70. DOI:10.1016/j.atherosclerosis.2015.08.010

IAXO-102 Preparation Products And Raw materials

Raw materials

Preparation Products

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1115270-63-7, IAXO-102Related Search:

IAXO-102

α-D-Glucopyranoside, methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-

Methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-α-D-glucopyranoside

IAXO102,IAXO 102,Toll-like Receptor (TLR),Inhibitor,IAXO-102,inhibit

IAXO-102 (CD14/TLR4 Antagonist) (synthetic)

IAXO-102 ，S0002

1115270-63-7

C35H71NO5