CITCO

Product Name: CITCO
CAS No.: 338404-52-7
Chemical Name: CITCO
Synonyms: CITCO,Inhibitor,inhibit,Apoptosis;6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime;Imidazo[2,1-b]thiazole-5-carboxaldehyde, 6-(4-chlorophenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime
CBNumber: CB4497318
Molecular Formula: C19H12Cl3N3OS
Formula Weight: 436.74
MOL File: 338404-52-7.mol

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CITCO Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: 28 mg/mL, soluble
form: solid
pka: 4.05±0.40(Predicted)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C6240
Product name: CITCO
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 16027
Product name: CITCO
Purity: ≥95%
Packaging: 5mg
Price: $72
Updated: 2024/03/01

Cayman Chemical

Product number: 16027
Product name: CITCO
Purity: ≥95%
Packaging: 10mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 16027
Product name: CITCO
Purity: ≥95%
Packaging: 25mg
Price: $301
Updated: 2024/03/01

TRC

Product number: C433048
Product name: CITCO
Packaging: 1mg
Price: $75
Updated: 2021/12/16

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CITCO Chemical Properties,Usage,Production

Uses

CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.

Definition

ChEBI: 1-[6-(4-chlorophenyl)-5-imidazo[2,1-b]thiazolyl]-N-[(3,4-dichlorophenyl)methoxy]methanimine is a member of imidazoles.

General Description

CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.

Biological Activity

citco, an imidazothiazole derivative, is a selective agonist of human car, with an ec50 value of 49 nm and > 50-fold selectivity to car over pregnane x receptor (pxr), and no activity on other nuclear receptors. upon activation with specific agonists, car translocates into the nucleus and binds to the response elements as monomers or car/rxr heterodimers. the car functions as a xenobiotic receptor, involved in detoxification and clearance of toxic substances from the liver. in addition, activation with selective car agonists such as citco has also been shown to inhibit growth and expansion of brain tumor stem cells.1. chakraborty s, kanakasabai s, bright jj. constitutive androstane receptor agonist citco inhibits growth and expansion of brain tumour stem cells. british journal of cancer, 2011, 104(3): 448-459.

Biochem/physiol Actions

CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.

storage

Desiccate at -20°C

CITCO Preparation Products And Raw materials

Raw materials

Preparation Products

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CITCO Suppliers

China 37 Switzerland 1 United Kingdom 1 United States 7 Global 46

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338404-52-7, CITCORelated Search:

Imidazo[2,1-b]thiazole-5-carboxaldehyde, 6-(4-chlorophenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime

6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime

CITCO,Inhibitor,inhibit,Apoptosis

338404-52-7

C19H12N3OCl3S