ChemicalBook > CAS DataBase List > A-317491 DISODIUM SALT

A-317491 DISODIUM SALT

Product Name
A-317491 DISODIUM SALT
CAS No.
475205-49-3
Chemical Name
A-317491 DISODIUM SALT
Synonyms
ABT 202;A-317491 sodium;A-317491 ，S8519;A 317491;A317491;4-tricarboxylic acid;A-317491 DISODIUM SALT;A-317491, 10 mM in DMSO;A-317491;A 317491;A317491;(S)-5-((3-phenoxybenzyl)(1;4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1
CBNumber
CB4497848
Molecular Formula
C33H27NO8
Formula Weight
565.57
MOL File
475205-49-3.mol
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A-317491 DISODIUM SALT Property

Boiling point:
840.4±65.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
H2O: ~34 mg/mL
pka
2.57±0.10(Predicted)
form 
powder
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19256
Product name
A-317491
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
19256
Product name
A-317491
Purity
≥98%
Packaging
5mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
19256
Product name
A-317491
Purity
≥98%
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
19256
Product name
A-317491
Purity
≥98%
Packaging
25mg
Price
$299
Updated
2024/03/01
TRC
Product number
A965315
Product name
A-317491
Packaging
5mg
Price
$130
Updated
2021/12/16
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A-317491 DISODIUM SALT Chemical Properties,Usage,Production

Uses

A-317491 is a P2X3 and P2X2/3 receptor antagonist.

in vivo

A-317491 (0.1-30 mg/kg; a single s.c.) dose-dependently reverses inflammatory mechanical hyperalgesia in rats[2].
A-317491 (3-30 mg/kg; a single .v.) exhibits the plasma half-life (7.38 h), clearance rate (1.83 L/h/kg), and volume of distribution (0.17 L/kg)[2].

Animal Model:Male adult Sprague-Dawley rats received an intraplantar injection of Freund's complete adjuvant[2]
Dosage:0.1, 1, 3, 10, 30 mg/kg
Administration:A single s.c.
Result:Produced a dose-dependent reduction in mechanical hyperalgesia 1 h, 3 h and 5 h post-administration.

IC 50

P2X3 Receptor

A-317491 DISODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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A-317491 DISODIUM SALT Suppliers

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475205-49-3, A-317491 DISODIUM SALTRelated Search:


  • (S)-5-((3-phenoxybenzyl)(1
  • 4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1
  • 4-tricarboxylic acid
  • A 317491;A317491;(S)-5-((3-PHENOXYBENZYL)(1;2;3;4-TETRAHYDRONAPHTHALEN-1-YL)CARBAMOYL)BENZENE-1;2;4-TRICARBOXYLIC ACID; SODIUM SALT HYDRATE
  • A-317491 DISODIUM SALT
  • (S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbaMoyl)benzene-1,2,4-tricarboxylic acid
  • 5-[[(3-Phenoxybenzyl)[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid
  • A-317491 sodium
  • A-317491;A 317491;A317491
  • A 317491;A317491
  • ABT 202
  • 1,2,4-Benzenetricarboxylic acid, 5-[[[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-
  • flux,calcium,P2X Receptor,A 317491,Inhibitor,neuropathic,inhibit,P2X2/3,A317491,P2X3,P2XRs,pain,A-317491,inflammatory
  • A-317491, 10 mM in DMSO
  • A-317491 ，S8519
  • 475205-49-3