LY 303511
- Product Name
- LY 303511
- CAS No.
- 154447-38-8
- Chemical Name
- LY 303511
- Synonyms
- NV-128 (NV 128;LY303511, >=98%;LY-303511(Nv-128);LY 303511; LY303511;LY 303511, PI3-kinase inhibitor;8-phenyl-2-(piperazin-1-yl)-4H-chromen-4-one;8-Phenyl-2-(1-piperazinyl)-4H-1-benzopyran-4-one;2-(1-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 8-phenyl-2-(1-piperazinyl)-;LY 303511 dihydrochloride, Negative control for LY 294002
- CBNumber
- CB4498214
- Molecular Formula
- C19H18N2O2
- Formula Weight
- 306.36
- MOL File
- 154447-38-8.mol
LY 303511 Property
- Boiling point:
- 496.1±45.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
- form
- Amber solid
- pka
- 9.20±0.10(Predicted)
- color
- amber
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 440203
- Product name
- LY 303511 - CAS 154447-38-8 - Calbiochem
- Purity
- A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002.
- Packaging
- 1mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- L503120
- Product name
- LY303511
- Packaging
- 250mg
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- A3568
- Product name
- LY303511
- Packaging
- 5mg
- Price
- $147
- Updated
- 2021/12/16
- Product number
- A3568
- Product name
- LY303511
- Packaging
- 50mg
- Price
- $982
- Updated
- 2021/12/16
- Product number
- API0008038
- Product name
- LY 303511
- Purity
- 95.00%
- Packaging
- 1MG
- Price
- $192.15
- Updated
- 2021/12/16
LY 303511 Chemical Properties,Usage,Production
Uses
LY 303511 is an inactive analog of the phosphoinositide 3-kinase inhibitor LY294002.
Definition
ChEBI: 8-phenyl-2-(1-piperazinyl)-1-benzopyran-4-one is a N-arylpiperazine.
Biological Activity
Negative control compound with respect to LY 294004 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-onehydrochloride ) PI 3-kinase inhibitory activity. Blocks voltage-gated potassium (K v ) channels (IC 50 = 64.6 μ M) and inhibits IL-1 β -stimulated NF- κ B activation, attenuating MCP-1 expression. Anti-proliferative.
in vivo
Intraperitoneal administration of vehicle or LY303511 (10 mg/kg/day) is performed when tumors reach a volume of ~150 mm3, at which time 35 mice have developed a tumor. After 21 days, >15% of the mice require euthanasia because of excessive tumor growth, and these data are censored due to unreliable estimates of average tumor volume. The administration of LY303511, 10 mg/kg/day, is sufficient to inhibit PC-3 tumor growth in vivo[4].
LY 303511 Preparation Products And Raw materials
Raw materials
Preparation Products
LY 303511 Suppliers
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View Lastest Price from LY 303511 manufacturers
- Product
- LY 303511 154447-38-8
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- LY 303511 154447-38-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kgs
- Release date
- 2019-12-17