NS 3694
- Product Name
- NS 3694
- CAS No.
- 426834-38-0
- Chemical Name
- NS 3694
- Synonyms
- Apoptosis Inhibitor II, NS3694;Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem;Benzoic acid, 4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;NS 3694,Inhibitor,Apaf-1,Apoptosis,inhibit,caspase-9,NS-3694,apoptosome inhibitor,NS3694,cytochrome c
- CBNumber
- CB4498300
- Molecular Formula
- C15H10ClF3N2O3
- Formula Weight
- 358.7
- MOL File
- 426834-38-0.mol
NS 3694 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: 22 mg/mL, soluble
- form
- solid
- color
- Off-white to light yellow
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- N7787
- Product name
- NS3694
- Purity
- ≥98%, powder
- Packaging
- 5mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 178494
- Product name
- Apoptosis Inhibitor II, NS3694
- Packaging
- 10mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- 19190
- Product name
- NS3694
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 19190
- Product name
- NS3694
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- N7787
- Product name
- NS3694
- Purity
- ≥98%, powder
- Packaging
- 25mg
- Price
- $326
- Updated
- 2024/03/01
NS 3694 Chemical Properties,Usage,Production
Description
Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.
Uses
NS3694 is a suppressor of the formation of apoptosome Apaf-1.
Definition
ChEBI: 4-chloro-2-[[oxo-[3-(trifluoromethyl)anilino]methyl]amino]benzoic acid is a member of ureas.
in vitro
previous study found that ns3694, and its two analogs (ns1764 and ns1784) were well-tolerated by mcf-7s1 breast cancer cells at concentrations up to 100, 50, and 25 μm, respectively. moreove, all three compounds could not inhibit recombinant caspase 9 and caspase 3 at concentrations ranging from 25 to 100 μm. in addition, ns3694 was able to inhibit the co-immunoprecipitation of caspase 9 and apaf-1 from hela cell cytosol stimulated by cytochrome c and datp. ns3694 could also inhibit the formation of the active 700-kda apoptosome complex, but had no effect on tnf-induced caspase-independent death of wehi-s cells. ns3694 did not inhibit fasl-induced caspase activation or death in type i cells neither [1].
IC 50
approximately 50 μm for cytochrome c-induced caspase activation in hela cell cytosolic extracts
References
[1] lademann, u. ,cain, k.,gyrd-hansen, m., et al. diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. mol.cell biol. 23(21), 7829-7837 (2003).
NS 3694 Preparation Products And Raw materials
Raw materials
Preparation Products
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