IOCETAMIC ACID (200 MG) Property

Melting point:

224-225° (NL 6515305); mp range 191-212° (Korver); Consists of 2 isomers having mps 232° and 200-201°

Boiling point:

658.2±55.0 °C(Predicted)

Density 

2.2000 (rough estimate)

refractive index 

1.7400 (estimate)

pka

4.0(at 25℃)

Water Solubility 

5.286g/L(37 ºC)

Stability:

Stable. Incompatible with strong oxidizing agents.

Safety

Hazardous Substances Data

16034-77-8(Hazardous Substances Data)

Toxicity

LD50 in rats (g/kg): 7.1 orally; 0.70 i.v. (Janbroers)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

IOCETAMIC ACID (200 MG) Chemical Properties,Usage,Production

Originator

Cholebrine,Nicholas

Uses

Diagnostic aid (radiopaque medium).

Definition

ChEBI: 3-(N-acetyl-3-amino-2,4,6-triiodoanilino)-2-methylpropanoic acid is an aromatic amide.

Manufacturing Process

A mixture of equimolecular amounts of m-nitraniline (69.0 g), methacrylic acid (43.0 g), and pyridine (39.5 g) was heated to 125°C for 20 h, and was then poured into 500 ml water. A semi-crystalline product separated from the liquid. The supernatant liquid was decanted and 500 ml fresh water was added. The pH was adjusted to 7-7.5 by means of sodium hydroxide. The precipitate was filtered with suction and washed with water. When the filtrate was acidified with acetic acid, a precipitate of N-(3-nitrophenyl)-β-aminoisobutyric acid was formed. When filtered, washed with water and dried, it weighed 56.0 g and had a melting point of 130°-131°C (recryst. from alcohol). The yield was 50% based on nitraniline.
0.25 mol (56.0 g) N-(3-nitrophenyl)-β-aminoisobutyric acid, prepared as described above, 160 ml glacial acetic acid, and 40 ml acetic anhydride were heated 48 h to 50°C, and the reaction mixture was poured into 600 ml water. A crystalline precipitate of N-acetyl-N-(3-nitrophenyl)-β-aminoisobutyric acid formed gradually. When recovered, it weighed 56.0 g (84% yield). Melting point 146°-148°C.
100.0 g N-acetyl-N-(3-nitrophenyl)-β-amino-isobutyric acid were dissolved in 1 L water and 40 ml 25% aqueous ammonia, and the solution was hydrogenated in the presence of about 10.0 g Raney nickel at 20°C and about 450 p.s.i. until the pressure drop indicated the complete conversion of the NO2 groups to NH2. Thus N-acetyl-N-(3-aminophenyl)-β-amino-isobutyric acid was obtained.
The solution of N-acetyl-N-(3-aminophenyl)-β-amino-isobutyric acid was filtered after standing overnight, mixed with an equal volume of acetic acid, and there after with a solution of 275.0 g iodine monochloride and 200.0 g sodium chloride in 1 L water. The mixture was kept at 50°C with stirring for 48 h. Light brown crystals of crude N-acetyl-N-(2,4,6-triiodo-3-aminophenyl)- β-amino-isobutyric acid precipitated, were filtered off, washed with water, and dried. They weighed 195.0 g (84.5% yield based on N-acetyl-N 3-nitrophenylp-amino-isobutyric acid).

brand name

Cholebrine (Mallinckrodt).

Therapeutic Function

Diagnostic aid

Hazard

Low toxicity by ingestion.