ALAMETHICINRESEARCH GRADE

Product Name: ALAMETHICINRESEARCH GRADE
CAS No.: 27061-78-5
Chemical Name: ALAMETHICINRESEARCH GRADE
Synonyms: Alamethicin (U-22324);ALAMETHICINRESEARCH GRADE;Alamethicin, Ready Made Solution;alamethicin from trichoderma viride;Alamethicin, Ready Made Solution from Trichoderma viride;Peptaibol coMplex. Additional synonyMs for the Major coMponent, alaMethicin I: AlaMethicin F30, AlaMethicin-gaMMa, U 22324;Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH2)-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH2)-phenylalaninol;Almethicin, Antibiotic U-22324, 6-(2-methylalanine)-8-L-leucine-9-de-L-valine-12-(2-methylalanine)-13a-endo-(2-methylalanine)-18-L-glutamine-19-(N(1)-(1-(hydroxymethyl)-3-methylbutyl)-L-glutamamide)-];N-Acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-α-glutamyl-N1;(3S,12R)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((R)-1-(2-AcetaMido-2-Methylpropanoyl)pyrrolidin-2-yl)-15-(3-aMino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,2,18,18,24,24,33,33-dodecaMethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,1
CBNumber: CB4500700
Molecular Formula: C92H150N22O25
Formula Weight: 1964.3078
MOL File: 27061-78-5.mol

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ALAMETHICINRESEARCH GRADE Property

Flash point:: 87℃
storage temp.: -20°C
solubility: Soluble in DMSO (up to 25 mg/ml) or in Methanol (up to 10 mg/ml).
form: DMSO solution
color: Off-white
BRN: 5213858
Stability:: Stable.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 3462 6.1/PG 3
WGK Germany: 3
F: 10-21
HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A4665
Product name: Alamethicin from Trichoderma viride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $299
Updated: 2024/03/01

Sigma-Aldrich

Product number: A4665
Product name: Alamethicin from Trichoderma viride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $510
Updated: 2024/03/01

Sigma-Aldrich

Product number: A5361
Product name: Alamethicin, Ready Made Solution from Trichoderma viride
Purity: 5?mg/mL in DMSO, sterile; 0.2 μm filtered
Packaging: 500μl
Price: $286
Updated: 2024/03/01

Cayman Chemical

Product number: 11425
Product name: Alamethicin
Purity: ≥90%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 11425
Product name: Alamethicin
Purity: ≥90%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

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ALAMETHICINRESEARCH GRADE Chemical Properties,Usage,Production

Description

Alamethicin is an antibiotic peptide belonging to a class of membrane active peptides of fungal origin called peptaibols. It contains an unusual amphiphilic amino acid, 2-aminoisobutyric acid, which strongly induces helical peptide structures and forms voltage-gated ion channels in the lipid bilayers of cell membranes. Alamethicin is often used to study ion channel assembly, voltage gating, and peptide-membrane interactions. Alamethicin is also widely used as agent to induce various physiological and defense responses in eukaryotic cells including plants.

Chemical Properties

solid

Uses

Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used for studying membrane interactions of antimicrobial peptides.

Uses

Alamethicin, Ready Made Solution from Trichoderma viride has been used :

In the uridine 5′-diphospho-glucuronosyltransferase activity assay.
To determine the Na, K-ATPase activity in permeabilized bovine nonpigmented epithelium cells.
In methylcrotonyl-CoA carboxylase activity assay.

Uses

Alamethicin is an acidic linear peptaibol complex with potent antibiotic activity, containing 20 “amino acids”, with acetyl and phenylalaninol termini, produced by Trichoderma sp.. Alamethicin F30 acts an ionopohore, transporting ions through membranes and artificial lipid membranes and forming voltage-dependent ion channels in lipid bilayer membranes. Alamethicin is co-produced with a parallel, neutral, linear peptaibol complex (alamethicin F50). The relative composition of alamethicin is a variable mixture of the acidic and neutral complexes, but reports on alamethacin do not generally specify the ratio of F50 to F30, and comparative data between the complexes is scant.

General Description

Alamethicin belongs to the peptaibol family of antimicrobial peptides. It is mainly composed of hydrophobic amino acids. It possess a helical structure with a movable hinge region at Gly-11 position.

Biochem/physiol Actions

Alamethicin is a 20-amino acid channel-forming peptide antibiotic isolated from the fungus Trichoderma viride. Alamethicin consists of several isoforms, for which structural information has been published. Alamethicin forms voltage-dependent channels across lipid bilayer membranes. The Alamethicin channel is built by a bundle of helical monomers forming a water filled transmembrane pore. The conductivity level of the channel is determined by the number of associated helical monomers (3-12), which generates a non aligned supermolecular structure with an aqueous core through which ions can cross lipid membranes. Alamethicin catalyzes the exchange of protons for monovalent cations with little difference in affinities and has the ability to transport cations through biological and artificial lipid membranes. Alamethicin can be used for the permeabilization of mitochondria without affecting the outer or inner membranes.

in vitro

alamethicin was identified as an antibiotic peptide belonging to membrane active peptides of fungal origin with an unusual amphiphilic amino acid, 2-aminoisobutyric acid, which can induce helical peptide structures strongly, leading to the formation of voltage-gated ion channels in the cell membrane bilayers. alamethicin is also widely used as agent to induce various defense responses and physiological in eukaryotic cells [1]. in addition, alamethicin was quite often used to evaluate voltage gating, ion channel assembly, as well as peptide-membrane interactions [2, 3].

Purification Methods

Recrystallise alamethicin from MeOH. [Panday et al. J Am Chem Soc 99 8469 1977.] The acetate has m 195-180o from MeOH/Et2O, and the acetate-methyl ester [64936-53-4] has m 145-140o from aqueous MeOH.

References

1) Woolley?et al. (2007),?Channel-forming activity of alamethicin: effects of covalent tethering; Biodivers.,?4?1323 2) Quist?et al. (1989),?Regulation of polyphosphoinositide synthesis in cardiac membranes; Arch. Biochem. Biophys.,?271?21 3) Nakagawa?et al. (1986),?Adenylate cyclase in sarcoplasmic reticulum of skeletal muscle: distribution orientation and regulation;?J. Cyclic Nuc. Prot. Phosphor. Res.,?11?237 4) Korge?et al. (2016),?Reactive oxygen species production in cardiac mitochondria after complex I inhibition: Modulation by substrate-dependent regulation of the NADH/NAD(+) ratio; Free Radic. Biol. Med.,?96?22

ALAMETHICINRESEARCH GRADE Preparation Products And Raw materials

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Preparation Products

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ALAMETHICINRESEARCH GRADE Suppliers

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View Lastest Price from ALAMETHICINRESEARCH GRADE manufacturers

Wuhan Xinhao Biotechnology Co., Ltd

Product: Alamethicin 27061-78-5
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-01-18

Career Henan Chemical Co

Product: ALAMETHICINRESEARCH GRADE 27061-78-5
Price: US $1.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: g/kg/Ton
Release date: 2019-12-25

27061-78-5, ALAMETHICINRESEARCH GRADERelated Search:

(+/-)-Verapamil hydrochloride Minoxidil N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Dofetilide ALAMETHICIN 5 MG ALAMETHICINRESEARCH GRADE 10 MG ALAMETHICINRESEARCH GRADE

Peptaibol coMplex. Additional synonyMs for the Major coMponent, alaMethicin I: AlaMethicin F30, AlaMethicin-gaMMa, U 22324

Alamethicin, Ready Made Solution from Trichoderma viride

Alamethicin (U-22324)

ALAMETHICINRESEARCH GRADE

alamethicin from trichoderma viride

Almethicin, Antibiotic U-22324, 6-(2-methylalanine)-8-L-leucine-9-de-L-valine-12-(2-methylalanine)-13a-endo-(2-methylalanine)-18-L-glutamine-19-(N(1)-(1-(hydroxymethyl)-3-methylbutyl)-L-glutamamide)-]

Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH2)-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH2)-phenylalaninol

(3S,12R)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((R)-1-(2-AcetaMido-2-Methylpropanoyl)pyrrolidin-2-yl)-15-(3-aMino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,2,18,18,24,24,33,33-dodecaMethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,1

N-Acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-α-glutamyl-N1

Alamethicin, Ready Made Solution

27061-78-5

C92H150N22O25

antibiotic

Ion transporter and other ion channel