N-Boc-propargylamine

Product Name: N-Boc-propargylamine
CAS No.: 92136-39-5
Chemical Name: N-Boc-propargylamine
Synonyms: tert-butyl prop-2-yn-1-ylcarbaMate;tert-butyl N-(prop-2-yn-1-yl)carbaMate;tert-butyl prop-2-ynylcarbaMate;tert-butyl N-prop-2-ynylcarbamate;N-Boc-proparg;N-Boc-propargyL;N-boc-aminopropyne;Boc-propargylamine;N-Boc-propargylamine;N-Boc-2-propyn-1-amine
CBNumber: CB4500977
Molecular Formula: C8H13NO2
Formula Weight: 155.19
MOL File: 92136-39-5.mol

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N-Boc-propargylamine Property

Melting point:: 40-44 °C
Boiling point:: 170°C/14mmHg(lit.)
Density: 0.990±0.06 g/cm3(Predicted)
Flash point:: 93°(199°F)
storage temp.: 2-8°C
solubility: Soluble in chloroform.
pka: 11.24±0.46(Predicted)
form: Solid
color: Pale Yellow to Dark Yellow
Sensitive: Moisture Sensitive
InChI: InChI=1S/C8H13NO2/c1-5-6-9-7(10)11-8(2,3)4/h1H,6H2,2-4H3,(H,9,10)
InChIKey: DSPYCWLYGXGJNJ-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCC#C

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-52/53
Safety Statements: 26-36/37-61
RIDADR: UN3259
WGK Germany: 3
HazardClass: 8
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 687146
Product name: N-Boc-propargylamine
Purity: 97%
Packaging: 5g
Price: $109
Updated: 2025/07/31

TCI Chemical

Product number: B4472
Product name: N-(tert-Butoxycarbonyl)propargylamine
Purity: >98.0%(GC)
Packaging: 1g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: B4472
Product name: N-(tert-Butoxycarbonyl)propargylamine
Purity: >98.0%(GC)
Packaging: 5g
Price: $69
Updated: 2025/07/31

GFS CHEMICALS

Product number: 18281
Product name: N-BOCPROPARGYLAMINE
Packaging: 5G
Price: $85.05
Updated: 2021/12/16

TRC

Product number: B664260
Product name: N-Boc-propargylamine
Packaging: 25g
Price: $325
Updated: 2021/12/16

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N-Boc-propargylamine Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Low Melting Solid

Uses

N-Boc-propargylamine is used in the preparation of triazolobenzylidene-thiazolopyrimidines which act as CDC25 phosphatase inhibitors. Also used in the synthesis of β-glucan polysaccharide analogs.

Uses

N-Boc-propargylamine is used to prepare triazolobenzylidene-thiazolopyrimidines. which act as CDC25 phosphatase inhibitors. Further, it is used for the synthesis of beta-glucan polysaccharide analogs. In addition to this, it is involved in the Pauson-Khand (PK) reaction of norbornadiene and N-Boc-propargylamine to prepare 4,5-disubstituted cyclopentenones .

Synthesis

24424-99-5

2450-71-7

92136-39-5

Di-tert-butyl dicarbonate (17.5 g, 80.0 mmol, 1.0 eq.) was slowly added dropwise to a dichloromethane solution (160 mL) of propargylamine (5.49 mL, 80.0 mmol, 1.0 eq.) at 0 °C. The reaction mixture was stirred at 0 °C for 1 h before the solvent was removed by distillation under reduced pressure. The resulting colorless oil was dried overnight under high vacuum to afford N-Boc-aminopropargyl (12.4 g, quantitative yield) as a white solid, which can be used in subsequent reactions without further purification. The spectral data of the product were consistent with those reported in the literature: Rf = 0.38 (hexane/ethyl acetate, 9:1); melting point = 41-42 °C (literature value:[1] 40-44 °C).1H NMR (500 MHz, CDCl3): δ (ppm) 4.94 (broad peak, 1H), 3.91 (broad double peak, J = 2.5 Hz, 2H), 2.23 (triple peak, J = 2.5 Hz, 1H). 2.5Hz, 1H), 1.45 (single peak, 9H).13C NMR (126MHz, CDCl3): δ (ppm) 155.2, 80.1, 79.9, 71.1, 28.2.

References

[1] Tetrahedron Letters, 2011, vol. 52, # 17, p. 2199 - 2202
[2] Organic Letters, 2014, vol. 16, # 9, p. 2430 - 2433
[3] European Journal of Organic Chemistry, 2015, vol. 2015, # 32, p. 7091 - 7113
[4] Patent: US2004/254231, 2004, A1
[5] Angewandte Chemie - International Edition, 2011, vol. 50, # 6, p. 1338 - 1341

N-Boc-propargylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-propargylamine Suppliers

Americas 1 Canada 1 China 178 Europe 2 Germany 3 India 4 Japan 2 Switzerland 3 United Kingdom 6 United States 26 Global 226

NanTong Chemistar Chemical Co.,Ltd

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Beijing HwrkChemical Technology Co., Ltd

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Energy Chemical

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View Lastest Price from N-Boc-propargylamine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: N-Boc-propargylamine 92136-39-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Boc-propargylamine 92136-39-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Boc-propargylamine 92136-39-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

92136-39-5, N-Boc-propargylamineRelated Search:

Propargyl bromide N-BOC-piperidine-4-carboxylic acid Diazomethane Methyl propiolate Bis(2-ethylhexyl)amine Aniline 3-Chloropropyne Propiolic Acid 3-Amino-1,2-propanediol :(S)-2-Methyl-3-(2-propynyl)-4-oxocyclopent-2-enyl-(lR)-cis,trans-2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate PROPARGYLAMINE Ethyl propiolate DI-TERT-BUTYL ETHER Propargyl alcohol rich-d-t-Prallethrin N-Boc-propargylamine

N-prop-2-ynylcarbamic acid tert-butyl ester

N-(tert-BUTOXYCARBONYL)PROPARGYLAMINE, 98%N-(tert-BUTOXYCARBONYL)PROPARGYLAMINE, 98%N-(tert-BUTOXYCARBONYL)PROPARGYLAMINE, 98%

N-(tert-Butoxycarbonyl)propargyl amine

N-Boc-propargylamine

(2-Propynyl)carbamic acid tert-butyl ester

N-(2-Propynyl)-carbamic acid tert-butyl ester

N-(2-Propynyl)carbamic acid tert-butyl ester

N-Propargylcarbamic acid tert-butyl ester

Propargylcarbamic acid tert-butyl ester

N-(tert-butyloxy)carbonyl propargylamine

Carbamic acid, 2-propynyl-, 1,1-dimethylethyl ester (9CI)

tert-butyl N-(prop-2-yn-1-yl)carbaMate

tert-butyl prop-2-yn-1-ylcarbaMate

CarbaMic acid, N-2-propyn-1-yl-, 1,1-diMethylethyl ester

tert-butyl prop-2-ynylcarbaMate

N-Boc-propargyl-1-aMine

N-Boc-propargylaMine 97%

N-Boc-2-propyn-1-amine

tert-butyl N-prop-2-ynylcarbamate

N-boc-aminopropyne

N-(tert-Butoxycarbonyl)propargylamine&gt

N-Boc-proparg

N-Boc-propargyL

tert-Butyl 2-Propynylcarbamate

Boc-propargylamine

N-2-Propyn-1-yl-carbamic acid tert-butyl ester

<i>N</i>-Boc-propargylamine

N-Boc-prop-2-ynylamine 98%

N-(tert-Butoxycarbonyl)propargylamine - [B2432]

92136-39-5

92316-39-5

API intermediates

Nitrogen Compounds

Organic Building Blocks

Protected Amines

N-BOC

Miscellaneous