2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97
- Product Name
- 2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97
- CAS No.
- 199328-31-9
- Chemical Name
- 2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97
- Synonyms
- 5-Chlorosulfonyloxindole;2-OXOINDOLINE-5-SULP;Indolone-5-sulfonyl chloride;5-CHLOROSULPHONYL-2-OXINDOLE;5-chlorosulfonyl-2-indolinone;2-Oxindole-5-sulfonyl chloride;2-Oxindole-5-sulphonyl chloride;2-Oxindole-5-sulphonylchloride97%;2-Oxoindoline-5-sulphonyl chloride;2-Oxindole-5-sulphonyl chloride 97%
- CBNumber
- CB4501358
- Molecular Formula
- C8H6ClNO3S
- Formula Weight
- 231.66
- MOL File
- 199328-31-9.mol
2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97 Property
- Melting point:
- >160
- Boiling point:
- 445.6±45.0 °C(Predicted)
- Density
- 1.568±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.34±0.20(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- Hazard Codes
- C
- Hazard Note
- Corrosive
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- O857405
- Product name
- 2-Oxo-5-indolinesulfonylChloride
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- OR8665
- Product name
- 2-Oxindole-5-sulphonylchloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $324
- Updated
- 2021/12/16
- Product number
- OR8665
- Product name
- 2-Oxindole-5-sulphonylchloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 8H62-5-V6
- Product name
- 2-Oxindole-5-sulfonyl chloride
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $154
- Updated
- 2021/12/16
- Product number
- 084450
- Product name
- 2-Oxoindoline-5-sulfonyl chloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $488
- Updated
- 2021/12/16
2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97 Chemical Properties,Usage,Production
Uses
2-Oxo-5-indolinesulfonyl Chloride is a reactant used in the preparation of bis-indole-substituted pyridines and piperazinediones derivatives with potential antitumor activity. Also used in the preparation of antitumor 3,5-substituted indolin-2-one derivatives.
Synthesis
59-48-3
199328-31-9
General procedure for the synthesis of 2-oxoindoline-5-sulfonyl chloride from 2-indolone: Chlorosulfonic acid (27 mL, 408 mmol) was slowly added dropwise to indolin-2-one (13.3 g, 100 mmol) under stirring, and the dropwise acceleration was controlled to keep the reaction temperature below 30 °C. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 1.5 h, followed by warming up to 68 °C for 1 h. The reaction was then carried out at room temperature for 1.5 h. The reaction temperature was increased to 68 °C. Upon completion of the reaction, the mixture was cooled to room temperature and carefully poured into water. The precipitated solid product was collected by vacuum filtration, washed with water and dried in a vacuum oven to afford 2-oxoindoline-5-sulfonyl chloride (3.02 g, 13.03 mmol, 98% yield), which can be used in subsequent reactions without further purification. The melting point of the product was 180-185 °C. 1H NMR (δ, ppm): 3.46 (s, 2H, CH2), 6.74 (d, 1H, J = 7.7 Hz, Ar), 7.42-7.46 (m, 2H, Ar), 10.48 (br s, 1H). 13C NMR (δ, ppm): 175.89, 143.68, 139.71, 124.55, 121.32, 107.39, 35.16. Elemental analysis (C8H6ClNO3S) Calculated values: C 41.48, H 2.61, N 6.05, S 13.84; measured values: C 41.57, H 2.72, N 6.14, S 13.92. S 13.92.
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 105, p. 274 - 288
[2] Journal of Antibiotics, 2018, vol. 71, # 10, p. 887 - 897
[3] Patent: CN104211632, 2016, B. Location in patent: Paragraph 0081; 0082
[4] Patent: WO2011/119777, 2011, A2. Location in patent: Page/Page column 26
[5] European Journal of Medicinal Chemistry, 2008, vol. 43, # 4, p. 755 - 762
2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97 manufacturers
- Product
- 2-OXOINDOLINE-5-SULPHONYL CHLORIDE 97 199328-31-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02