ChemicalBook > CAS DataBase List > BOHEMINE

BOHEMINE

Product Name
BOHEMINE
CAS No.
189232-42-6
Chemical Name
BOHEMINE
Synonyms
3-{[6-(Benzylamino)-9-Isopropyl-9H-Purin-2-Yl]Amino}-1-Propanol;3-((6-(benzylaMino)-9-isopropyl-9H-purin-2-yl)aMino)propan-1-ol;1-Propanol,3-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-;CDK,MAb,inhibit,rearrangement,Bohemine,proteosynthesis,Extracellular signal regulated kinases,Inhibitor,Cyclin dependent kinase,dk9/cyclin T1,ERK,cytoskeleton,Cdk2/cyclin A,purine,anti-cancer,Cdk2/cyclin E
CBNumber
CB4503170
Molecular Formula
C18H24N6O
Formula Weight
340.42
MOL File
189232-42-6.mol
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BOHEMINE Property

Melting point:
101-103 °C
Boiling point:
589.4±60.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
chloroform: 50 mg/mL, soluble
form 
powder
pka
14.94±0.10(Predicted)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21073
Product name
Bohemine
Purity
≥98%
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
21073
Product name
Bohemine
Purity
≥98%
Packaging
5mg
Price
$156
Updated
2024/03/01
ApexBio Technology
Product number
B6101
Product name
Bohemine
Packaging
5mg
Price
$110
Updated
2021/12/16
AK Scientific
Product number
0285CA
Product name
Bohemine
Packaging
5mg
Price
$271
Updated
2021/12/16
ChemScene
Product number
CS-0012711
Product name
Bohemine
Purity
≥98.0%
Packaging
5mg
Price
$320
Updated
2021/12/16
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BOHEMINE Chemical Properties,Usage,Production

Definition

ChEBI: Bohemine is purine substituted on C-2, C-6 and N-9 with (3-hydroxypropyl)amino, benzylamino and isopropyl groups respectively; a synthetic, cell-permeable, cyclin-dependent kinase (CDK) inhibitor that is structurally similar to olomoucine and roscovitine. It has a role as an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor.

Biological Activity

a highly conserved array of mechanisms regulating cyclin-dependent kinases (cdk), which govern the timing of cell cycle progression and division, has developed in eukaryotes. cdk inhibitors have been shown to play an key regulatory role in cell proliferation, differentiation, senescence, as well as programmed death.

in vitro

bohemine was applied to cultures of mouse hybridoma cells in order to evaluate its capacity of cell growth and the production of monoclonal antibody. results showed that addition of bohemine at concentrations in the range of 1-10 μm led to a short-term arrest of growth and monoclonal antibody production. such short-term suppression of cell functions was followed by a significant temporary increase of specific growth rate and specific production rate. in semicontinuous cultures, the steady-state viable cell density values showed a certain stimulation of cell growth in the presence of bohemine at micromolar concentrations, and growth inhibition at 10 and 30 μm [1].

in vivo

in mice, bohemine was found to be rapidly and completely metabolized and disappeared from circulation during the first 60 min following i.v. administration. moreover, the metabolites were eliminated by the hepatobiliary tract and also by renal excretion [2].

target

TargetValue
Cdk9/cyclin T1
()		 2.7 μM
Cdk2/cyclin E
()		 4.6 μM
Cdk2/cyclin A
()		 83 μM

IC 50

1 μm for cyclin-dependent kinase

References

[1] franek f,strnad m,havlícek l,siglerová v,fismolová i,eckschlager t. diverse effects of the cyclin-dependent kinase inhibitor bohemine: concentration- and time-dependent suppression or stimulation of hybridoma culture. cytotechnology.2001 jul;36(1-3):117-23.
[2] chmela z,vesel j,lemr k,rypka m,hanus j,havlícek l,krystof v,michnová l,fuksová k,lukes j. in vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route. drug metab dispos.2001 mar;29(3):326-34.

BOHEMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BOHEMINE Suppliers

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View Lastest Price from BOHEMINE manufacturers

Career Henan Chemical Co
Product
BOHEMINE 189232-42-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

189232-42-6, BOHEMINERelated Search:


  • 3-((6-(benzylaMino)-9-isopropyl-9H-purin-2-yl)aMino)propan-1-ol
  • 3-{[6-(Benzylamino)-9-Isopropyl-9H-Purin-2-Yl]Amino}-1-Propanol
  • 1-Propanol,3-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-
  • CDK,MAb,inhibit,rearrangement,Bohemine,proteosynthesis,Extracellular signal regulated kinases,Inhibitor,Cyclin dependent kinase,dk9/cyclin T1,ERK,cytoskeleton,Cdk2/cyclin A,purine,anti-cancer,Cdk2/cyclin E
  • 189232-42-6
  • C18H24N6O
  • Inhibitors