L-CYSTEINESULFINIC ACID MONOHYDRATE
- Product Name
- L-CYSTEINESULFINIC ACID MONOHYDRATE
- CAS No.
- 207121-48-0
- Chemical Name
- L-CYSTEINESULFINIC ACID MONOHYDRATE
- Synonyms
- 3-sulfino-l-alanine;Sulfino-L-alanine hydrate;L-Cysteinesulfinic Acid (hydrate);(2R)-2-aMino-3-sulfinopropanoic acid;L-Cysteinesulfinic acid Monohydrate 99%;Acetylcysteine impurity 20(monohydrate);
L -Cysteinesulfinic acid monohydrate;(1R)-1-amino-2-mercaptoethanesulfinic acid hydrate;L Cysteinesulfinic acid monohydrate,LCysteinesulfinic acid monohydrate,Metabotropic glutamate receptors,Inhibitor,L-Cysteinesulfinic acid,inhibit,mGluR - CBNumber
- CB4503615
- Molecular Formula
- HO2SCH2CH(NH2)CO2HH2O
- Formula Weight
- 171.17
- MOL File
- 207121-48-0.mol
L-CYSTEINESULFINIC ACID MONOHYDRATE Property
- Melting point:
- 163 °C (dec.)(lit.)
- storage temp.
- -20°C
- solubility
- Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- optical activity
- [α]25/D +24°, c = 1 in 1 M HCl
- Stability:
- Temperature Sensitive
- Major Application
- peptide synthesis
- InChI
- 1S/C3H7NO4S.H2O/c4-2(3(5)6)1-9(7)8;/h2H,1,4H2,(H,5,6)(H,7,8);1H2/t2-;/m0./s1
- InChIKey
- YQIXTMZYGQXTCZ-DKWTVANSSA-N
- SMILES
- [H]O[H].N[C@@H](CS(O)=O)C(O)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 270881
- Product name
- L-Cysteinesulfinic acid monohydrate
- Purity
- 99%
- Packaging
- 1g
- Price
- $874
- Updated
- 2026/03/19
- Product number
- 270881
- Product name
- L-Cysteinesulfinic acid monohydrate
- Purity
- 99%
- Packaging
- 250mg
- Price
- $201
- Updated
- 2023/06/20
- Product number
- 29597
- Product name
- L-Cysteinesulfinic Acid (hydrate)
- Packaging
- 50mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 29597
- Product name
- L-Cysteinesulfinic Acid (hydrate)
- Packaging
- 100mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- C4418
- Product name
- L-Cysteinesulfinic acid monohydrate
- Packaging
- 100mg
- Price
- $148
- Updated
- 2026/03/19
L-CYSTEINESULFINIC ACID MONOHYDRATE Chemical Properties,Usage,Production
Description
L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs). It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC50s = 120, 30, and 110 μM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC50s = 100, 100, and 2,000 μM, respectively). It selectively binds to mGluR1α (Ki = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (Kis = >10,000 nM for all). L-Cysteinesulfinic acid (1 mM) decreases mean arterial blood pressure and heart rate in rats when microinjected into the nucleus tractus solitarius (NTS). L-Cysteinesulfinic acid can be formed via oxidation of L-cysteine by reactive oxygen species (ROS), and conversion of cysteine to L-cysteinesulfinic acid in cysteine-containing peptide probes has been used to measure oxidative stress.
Chemical Properties
Off-White Solid
Uses
An amino acid derivative with neuropathological interest; Putative excitatory amino acid neurotransmitter.
Uses
L-Cysteinesulfinic acid monohydrate has been used in the fluorescence measurement of cysteine oxidation.
reaction suitability
reaction type: solution phase peptide synthesis
Biochem/physiol Actions
Cysteinesulfinic acid (CSA), also called 3-sulfinoalanine is synthesized by the conversion of sulfur to sulfinic acid in cysteine by the enzyme cysteine dioxygenase (CDO). CSA is a putative excitatory amino acid (EAA) with neurotransmitter functionality. It also regulates cardiovascular functions.
References
[1] TAKEMOTO Y. Cardiovascular actions of l-cysteine and l-cysteine sulfinic acid in the nucleus tractus solitarius of the rat[J]. Amino Acids, 2014, 46 7: 1707-1713. DOI: 10.1007/s00726-014-1733-z
[2] QI SHI. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 305 1: 131-142. DOI: 10.1124/jpet.102.047092
[3] CHUN-LAN KENG. Design of Peptide-Based Probes for the Microscale Detection of Reactive Oxygen Species[J]. Analytical Chemistry, 2017, 89 20: 10883-10888. DOI: 10.1021/acs.analchem.7b02544
L-CYSTEINESULFINIC ACID MONOHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-CYSTEINESULFINIC ACID MONOHYDRATE manufacturers
- Product
- L-Cysteinesulfinic acid monohydrate 207121-48-0
- Price
- US $1.90/g
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 19tons
- Release date
- 2021-12-09