MICROCYSTIN LA

Product Name: MICROCYSTIN LA
CAS No.: 96180-79-9
Chemical Name: MICROCYSTIN LA
Synonyms: toxinbe4;cyanoginosin-la;DIAQQISRBBDJIM-DRSCAGMXSA-N;Microcystin-leucine-alanine;Toxin be 4 (microcystis aeruginosa);Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-alanyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]
CBNumber: CB4503842
Molecular Formula: C46H67N7O12
Formula Weight: 910.064
MOL File: 96180-79-9.mol

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MICROCYSTIN LA Property

Boiling point:: 1237.0±65.0 °C(Predicted)
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: methanol: 2 mg/mL
pka: 3.03±0.70(Predicted)
form: Whitish film adhered to inside of the vial.
color: Colorless to off-white
EPA Substance Registry System: Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-.beta.-aspartyl-L-alanyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-.gamma.-glutamyl] (96180-79-9)

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28-36/37/38-43
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: GT2805000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H330Fatal if inhaled

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P361Remove/Take off immediately all contaminated clothing.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10007187
Product name: Microcystin-LA
Purity: ≥95%
Packaging: 25μg
Price: $189
Updated: 2024/03/01

Cayman Chemical

Product number: 10007187
Product name: Microcystin-LA
Purity: ≥95%
Packaging: 100μg
Price: $378
Updated: 2024/03/01

Cayman Chemical

Product number: 10007187
Product name: Microcystin-LA
Purity: ≥95%
Packaging: 1mg
Price: $3017
Updated: 2024/03/01

Cayman Chemical

Product number: 10007187
Product name: Microcystin-LA
Purity: ≥95%
Packaging: 500μg
Price: $1085
Updated: 2021/12/16

ChemScene

Product number: CS-0021541
Product name: Microcystin-LA
Packaging: 100ug
Price: $650
Updated: 2021/12/16

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MICROCYSTIN LA Chemical Properties,Usage,Production

Description

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock following consumption of freshwater in areas where the blue-green algae are endemic. The toxicity of microcystins is initiated by the inhibition of the catalytic activity of protein phosphatase (PP) 1 and PP2A. Microcystin-LA differs from the major microcystin variant LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with an IC₅₀ value of 0.3 nM.

Uses

Microcystin LA from algae has been used as a standard for liquid chromatography/mass spectrometry (LCMS) for toxin analysis.

Definition

ChEBI: Microcystin la is a peptide.

General Description

Microcystin is a small, monocyclic peptide, composed of seven amino acids connected via peptide bonds. It is a cyanotoxin with hepatotoxic and tumor promoting properties. Several algal genera like Anabaena, Aphanizomenon, Microcystis and Planktothrix produce microcystin. Microcystin has four congeners namely, -LR, -LA, -YR and -RR.

Biochem/physiol Actions

Microcystin LA inhibits protein phosphatase type 2A and protein phosphatase type 3 more potently than protein phosphatase type 1 (order of potency PP2A > PP3 > PP1). Induces neutrophil-activating chemokines and extracellular reactive oxygen species, possible mechanisms of its hepatotoxic effects.

MICROCYSTIN LA Preparation Products And Raw materials

Raw materials

Preparation Products

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MICROCYSTIN LA Suppliers

China 14 France 1 India 1 Switzerland 1 United States 4 Global 21

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96180-79-9, MICROCYSTIN LARelated Search:

Microcystin (N-Methyl-L)R ("MC(N-Me)LR") Algae bloom toxin, Biotoxin, Cyanobacterial toxin MICROCYSTIN YR Microcystin HtyR Algae bloom standard, Algae bloom toxin, Biotoxin, Cyanobacterial toxin Microcystin-WR microcystin LY

Microcystin-leucine-alanine

DIAQQISRBBDJIM-DRSCAGMXSA-N

cyanoginosin-la

toxinbe4

Toxin be 4 (microcystis aeruginosa)

Cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-alanyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl]

96180-79-9

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