2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID
- Product Name
- 2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID
- CAS No.
- 117724-63-7
- Chemical Name
- 2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID
- Synonyms
- -4-(trifL;e-5-carboxyL;2-Methyl-4-(trifluoromethyl);2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CAR;5-Carboxy-2-methyl-4-(trifluoromethyl)-1,3-thiazole;2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylicaci;2-methyl-4-(trifluoromethyl)- 5-Thiazolecarboxylic acid;5-Thiazolecarboxylic acid, 2-Methyl-4-(trifluoroMethyl)-
- CBNumber
- CB4511492
- Molecular Formula
- C6H4F3NO2S
- Formula Weight
- 211.16
- MOL File
- 117724-63-7.mol
2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID Property
- Melting point:
- 186～187℃
- Boiling point:
- 285.5±40.0 °C(Predicted)
- Density
- 1.570±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 1.97±0.36(Predicted)
- color
- White to Light yellow to Light orange
- InChI
- InChI=1S/C6H4F3NO2S/c1-2-10-4(6(7,8)9)3(13-2)5(11)12/h1H3,(H,11,12)
- InChIKey
- REKJPVUFKQYMHW-UHFFFAOYSA-N
- SMILES
- S1C(C(O)=O)=C(C(F)(F)F)N=C1C
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M3078
- Product name
- 2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic Acid
- Packaging
- 1G
- Price
- $22
- Updated
- 2025/07/31
- Product number
- M3078
- Product name
- 2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic Acid
- Packaging
- 5G
- Price
- $69
- Updated
- 2025/07/31
- Product number
- M219195
- Product name
- 2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic Acid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC10287
- Product name
- 2-Methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylicacid
- Packaging
- 250mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- CAPOM11111
- Product name
- 2-Methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylicacid
- Purity
- 98%
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic Acid can be used to prepare a fungicidal mixture.
Synthesis
117724-62-6
117724-63-7
General procedure for the synthesis of 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid from ethyl 2-methyl-4-trifluoromethyl-5-thiazolecarboxylate: 115 g of ethyl 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylate (0.102 mol) was dissolved in ethyl acetate at room temperature, and 50 g of 40% sodium hydroxide solution was added dropwise slowly into a reaction vessel with controlled The acceleration of the drop was controlled to maintain the temperature of the reaction system below 40 °C. After the dropwise addition, the reaction temperature was maintained and stirring was continued for 60 minutes. After the reaction was completed, the organic phase was separated and 10% hydrochloric acid solution was slowly added to the organic phase to adjust the pH value of the system to ≤2, at which time a large amount of solid precipitate precipitated. The precipitate was filtered and the filter cake was washed twice with 10% hydrochloric acid solution and subsequently dried in a vacuum oven. The resulting 2-methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid was a light yellow solid with a yield of 21.5 g, a purity of 98.8% and a reaction yield of 98.70%.
References
[1] Journal of Fluorine Chemistry, 2004, vol. 125, # 9, p. 1287 - 1290
[2] Patent: US4837242, 1989, A
[3] Patent: CN103145639, 2016, B. Location in patent: Paragraph 0035; 0036; 0037
[4] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 6, p. 3395 - 3402
2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID manufacturers
- Product
- 2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid 117724-63-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
- Product
- 2-METHYL-4-(TRIFLUOROMETHYL)-1,3-THIAZOLE-5-CARBOXYLIC ACID 117724-63-7
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-22
- Product
- 2-Methyl-4-(trifluoromethyl)thiazole-5-carboxylic acid 117724-63-7
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22