6H05 TFA

Product Name: 6H05 TFA
CAS No.: 2061344-88-3
Chemical Name: 6H05 TFA
Synonyms: 6H05 TFA;K-RAS INHIBITOR;6H05 TFA;Inhibitor,inhibit,6H05 (TFA),Ras,6H-05 (TFA)
CBNumber: CB45419656
Molecular Formula: C22H31ClF3N3O4S3
Formula Weight: 590.13
MOL File: 2061344-88-3.mol

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6H05 TFA Property

storage temp.: Store at -20°C
solubility: DMSO: ≥ 51 mg/mL (86.42 mM)
form: A crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17985
Product name: 6H05 (trifluoroacetate salt)
Packaging: 1mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 17985
Product name: 6H05 (trifluoroacetate salt)
Packaging: 25mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 17985
Product name: 6H05 (trifluoroacetate salt)
Packaging: 5mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 17985
Product name: 6H05 (trifluoroacetate salt)
Packaging: 10mg
Price: $333
Updated: 2024/03/01

ChemScene

Product number: CS-3428
Product name: 6H05TFA
Purity: 99.55%
Packaging: 10mg
Price: $294
Updated: 2021/12/16

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6H05 TFA Chemical Properties,Usage,Production

Description

The Ras family of small GTPases (H-Ras, K-Ras, and N-Ras) function as molecular switches, cycling between a GTP-bound active state and a GDP-bound inactive state, to turn on downstream Raf protein kinases. This initiates complex signaling pathways involved in cell growth, differentiation, and apoptosis. Mutations leading to aberrant Ras activation are frequently associated with various human cancers. 6H05 is a small molecule that allosterically binds to a mutant cysteine on oncogenic K-Ras(G12C), thus inhibiting its function. Binding of 6H05 to K-Ras(G12C) disrupts both switch-I and switch-II, altering the native nucleotide preference to favor GDP over GTP, which impedes binding to Raf. Because 6H05 is selective for mutant Cys-12, it does not affect wild-type K-Ras.

6H05 TFA Preparation Products And Raw materials

Raw materials

Preparation Products

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6H05 TFA Suppliers

China 11 United States 5 Global 16

Beijing Solarbio Science & Tecnology Co., Ltd.

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Amadis Chemical Company Limited

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InvivoChem

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Energy Chemical

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InvivoChem

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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Shanghai Aladdin Biochemical Technology Co.,Ltd.

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2061344-88-3, 6H05 TFARelated Search:

6H05 TFA

K-RAS INHIBITOR;6H05 TFA

Inhibitor,inhibit,6H05 (TFA),Ras,6H-05 (TFA)

2061344-88-3

CHClFNOS