ChemicalBook > CAS DataBase List > GLP-1 receptor agonist 1

GLP-1 receptor agonist 1

Product Name: GLP-1 receptor agonist 1
CAS No.: 2212020-52-3
Chemical Name: GLP-1 receptor agonist 1
Synonyms: LY3502970;OWL 833;Ogerlon;Orforglipron;0rforglipron;Orforglipron（LY3502970）;LY3502970 (Orforglipron);Orforglipron, 10 mM in DMSO;Research Grade Orforglipron;Orforglipron，PhEur/USP(DMF)
CBNumber: CB45419742
Molecular Formula: C48H48F2N10O5
Formula Weight: 882.97
MOL File: 2212020-52-3.mol

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GLP-1 receptor agonist 1 Property

Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (141.57 mM)
form: Solid
pka: 7.33±0.20(Predicted)
color: Off-white to light yellow
InChIKey: USUWIEBBBWHKNI-BBGRWQLENA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0043632
Product name: GLP-1receptoragonist1
Purity: 99.42%
Packaging: 5mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0043632
Product name: GLP-1receptoragonist1
Purity: 99.42%
Packaging: 10mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-0043632
Product name: GLP-1receptoragonist1
Purity: 99.42%
Packaging: 25mg
Price: $3900
Updated: 2021/12/16

ChemScene

Product number: CS-0043632
Product name: GLP-1receptoragonist1
Purity: 99.42%
Packaging: 50mg
Price: $6500
Updated: 2021/12/16

ChemScene

Product number: CS-0043632
Product name: GLP-1receptoragonist1
Purity: 99.42%
Packaging: 100mg
Price: $9950
Updated: 2021/12/16

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GLP-1 receptor agonist 1 Chemical Properties,Usage,Production

Description

Orforglipron (LY3502970) (GLP-1 receptor agonist 1) is GLP-1 receptor agonist extracted from patent WO2018056453A1, Compound 67.

History

Orforglipron is an oral, non-peptide, small-molecule glucagon-like peptide-1 receptor agonist developed by Eli Lilly and Company as a weight-loss drug. Currently, the drug is still in Phase III clinical trials and has not yet received approval from the U.S. Food and Drug Administration (FDA). Eli Lilly's CEO expects the FDA to approve its investigational oral weight-loss drug, orforglipron, by March 2026, and to submit an application for the treatment of type 2 diabetes by the end of 2026.

Uses

Glucagon-like peptide-1 (GLP-1) agonists (also known as GLP-1 receptor agonists, incretin mimetics, or GLP-1 analogs) represent a class of medications used to treat type 2 diabetes mellitus and, in some cases, obesity.

in vivo

Orforglipron (0.94-4.8 nM in plasma concentration, i.v., or 0.05-0.1 mg/mL, i.g. for 5 days) suppresses food intake in a dose-dependent manner, promotes insulin secretion and decreases blood glucose in cynomolgus monkey model^[1].
Orforglipron (0.05-1.35 mg/kg, i.g.) reaches C_max 2 hours after administration at all doses, exhibits proportional ratio of increase in plasma drug exposure to dose increase, indicates a dose-dependent absorption in the gastrointestinal tract^[1].

Pharmacokinetic Analysis of Orforglipron in cynomolgus monkey ^[1]

route	Dose (mg/kg)	T_max (h)	C_max (ng/mL)	AUC_0-24h (ng·h/mL)
i.g.	0.05	2.0	4.78	23.7
i.g.	0.15	2.0	20.7	135
i.g.	0.45	2.0	32.0	208
i.g.	1.35	2.0	148	1040

Animal Model:	cynomolgus monkey model^[1]
Dosage:	0.9-4.8 nM; 0.05-0.1 mg/mL
Administration:	continuous i.v. administration for 30 minutes until a plasma concentration of 0.9-4.8 nM at steady state; i.g. for 5 days with dose of 0.05-0.1 mg/mL
Result:	Increased insulin secretion and decreased plasma-glucose. Suppressed food intake in a dose-dependent manner.

GLP-1 receptor agonist 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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RongNa Biotechnology Co.,Ltd

Product: Orforglipron（LY3502970） 2212020-52-3
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-11-21

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Shaanxi Dideu New Materials Co. Ltd

Product: Orforglipron 2212020-52-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98
Supply Ability: 10000KGS
Release date: 2025-11-20

2212020-52-3, GLP-1 receptor agonist 1Related Search:

(S,E)-1-(4-fluoro-1-methyl-1H-indazol-5-yl)-3-(2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-1-(2-hydroxyvinyl)urea \\ 5-[(S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl]-1-[(1S,2S)-2-methyl-1-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)cyclopropyl]-1H-indole-2-carboxylic Acid 1H-Indole-2-carboxamide, N-methyl-N-phenyl-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]- (R)-1-(4-fluoro-1-methyl-1H-indazol-5-yl)-3-(2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)-1,3-dihydro-2H-imidazol-2-one 3-((1S,2R)-1-(5-((R)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-((R)-3- (3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1Himidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7- tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl)-2- methylcyclopropyl)-1,2,4-oxadiazol-5(4H)-one Ly3502970

1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indol-1-yl]-2-methylcy...

LY3502970

GLP-1 receptor agonist 1 USP/EP/BP

Orforglipron

Orforglipron（LY3502970）

LY3502970 (Orforglipron)

3-((1S,2S)-1-(5-((S)-2,2-dimethyltetrahydro-2H-pyran-4-yl)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl)-2-methylcyclopropyl)-1,2,4-oxadiazol-5(4H)-one

OWL 833

LY3502970|||GLP-1 receptor agonist 1

3-((1S,2S)-1-(5-((S)-2,2-Dimethyltetrahydro-2H-pyran-4-yl)-2-((S)-3-(3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl)-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carbonyl)-1H-indol-1-yl

Orforglipron, 10 mM in DMSO

Research Grade Orforglipron

1,2,4-Oxadiazol-5(2H)-one,3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazChemicalbookol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indol-1-yl]-2-methylcy

0rforglipron

3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indol-1-yl]-2-methylcyclopropyl]-1,2,4-Oxadiazol-5(2H)-one

Ogerlon

Orforglipron，PhEur/USP(DMF)

Orforglipron raw materials,Peptide customization

Orforglipron/GLP-1 receptor agonist 1

2212020-52-3

C48H48F2N10O5

ADVANCED INT.

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