LY2794193
- Product Name
- LY2794193
- CAS No.
- 2173037-97-1
- Chemical Name
- LY2794193
- Synonyms
- LY2794193;LY-2794193,LY2794193;Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-4-[(3-methoxybenzoyl)amino]-, (1S,2S,4S,5R,6S)-
- CBNumber
- CB45419777
- Molecular Formula
- C16H18N2O6
- Formula Weight
- 334.32
- MOL File
- 2173037-97-1.mol
LY2794193 Property
- Boiling point:
- 598.6±50.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- pka
- 1.78±0.60(Predicted)
- color
- White to off-white
- Water Solubility
- Water : 2 mg/mL (5.98 mM; ultrasonic and adjust pH to 14 with NaOH)
N-Bromosuccinimide Price
- Product number
- CS-0077322
- Product name
- LY2794193
- Purity
- 99.88%
- Packaging
- 5mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0077322
- Product name
- LY2794193
- Purity
- 99.88%
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0077322
- Product name
- LY2794193
- Purity
- 99.88%
- Packaging
- 50mg
- Price
- $2850
- Updated
- 2021/12/16
- Product number
- CS-0077322
- Product name
- LY2794193
- Purity
- 99.88%
- Packaging
- 100mg
- Price
- $3950
- Updated
- 2021/12/16
LY2794193 Chemical Properties,Usage,Production
Biological Activity
LY2794193 is a potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM, EC50=0.47 nM; hmGlu2 Ki=412 nM, EC50=47.5 nM).
in vitro
LY2794193 exhihits inhibition of spontaneous Ca 2+ oscillations in cultured rat cortical neurons with an EC 50 of 43.6 nM.
In the rat cortical neuron Ca 2+ oscillation assay, LY2794193 exhibits a biphasic inhibition of spontaneous Ca 2+ transients (high affinity EC 50 =0.44 nM; 48% of the total agonist response; low affinity EC 50 =43.6 nM; 52% of the total agonist response) with combined maximal agonist efficacy (E max ) of 66%. < /p>
in vivo
LY2794193 (1-30 mg/kg, sc), given 30 min prior to PCP (5 mg/kg, sc) leads a dose-related reduction in ambulations.
LY2794193 (1 mg/ kg; iv) exhibits moderate clearance (18.3 mL/min per kg) and volume of distribution (1.17 L/kg) with a calculated plasma half-life (T 1/2 ) of 3.1 h in Male Sprague-Dawley rats.
LY2794193 (3 mg/kg; sc) leads to the rapid appearance in the plasma (AUC=9.9 μM; C max =6.78 μM; T max =0.44 h) and a calculated bioavailability of 121% in male Sprague-Dawley rats.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 1, 3, 10, or 30 mg/kg < /td> |
| Administration: | Administrated sc; given 30 min prior to PCP (5 mg/kg, sc) |
| Result: | A dose-related reduction in ambulations was observed, with the 10 and 30 mg/kg dose groups found to be statistically significant. | < /tr>
target
| mGluR3 0.47 nM (EC 50 ) | mGluR3 0.927 nM (Ki) | mGluR2 47.5 (EC 50 ) | mGluR2 412 (Ki) |
LY2794193 Preparation Products And Raw materials
Raw materials
Preparation Products
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