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PAR-4 Agonist Peptide, amide TFA

Product Name
PAR-4 Agonist Peptide, amide TFA
CAS No.
1228078-65-6
Chemical Name
PAR-4 Agonist Peptide, amide TFA
Synonyms
AY-NH2 TFA);PAR-4-AP (TFA);PAR-4 Agonist Peptide, amide TFA;PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA;PAR-4 Agonist Peptide, amide TFA, 10 mM in DMSO;Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt;Thrombin receptors,PAR4 Agonist Peptide, amide TFA,Protease Activated Receptor (PAR),inhibit,AY-NH2,PAR-4 Agonist Peptide, amide,Inhibitor,PAR 4 Agonist Peptide, amide TFA;(S)-1-(L-Alanyl-L-tyrosyl)-N-(2-(((S)-6-amino-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-1-oxohexan-2-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate
CBNumber
CB45419803
Molecular Formula
C36H49F3N8O9
Formula Weight
794.83
MOL File
1228078-65-6.mol
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PAR-4 Agonist Peptide, amide TFA Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 250 mg/mL (314.54 mM)
form 
Solid
color 
White to off-white
Water Solubility 
H2O: >10mg/mL
Sequence
H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2
InChIKey
BGPJLFVICWHITH-HKJXYENISA-N
SMILES
OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCCC2C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A3227
Product name
Ala-Tyr-Pro-Gly-Lys-Phe-NH<SUB>2</SUB> trifluoroacetate salt
Purity
&#8805;98% (HPLC), lyophilized powder
Packaging
1 mg
Price
$226
Updated
2026/04/30
ChemScene
Product number
CS-0089115
Product name
PAR-4AgonistPeptide,amideTFA
Purity
99.97%
Packaging
1mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0089115
Product name
PAR-4AgonistPeptide,amideTFA
Purity
99.97%
Packaging
5mg
Price
$330
Updated
2021/12/16
ChemScene
Product number
CS-0089115
Product name
PAR-4AgonistPeptide,amideTFA
Purity
99.97%
Packaging
10mg
Price
$530
Updated
2021/12/16
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PAR-4 Agonist Peptide, amide TFA Chemical Properties,Usage,Production

Uses

4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.', 'AYPGKF- NH2 may be used for probing PAR4 signaling in culture systems and in platelets.

Biological Activity

AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation. Additionally, AYPGKF mediates the thrombin-induced release of endostatin from r at platelets.

in vivo

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1].

PAR-4 Agonist Peptide, amide TFA Preparation Products And Raw materials

Raw materials

Preparation Products

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PAR-4 Agonist Peptide, amide TFA Suppliers

China 34 United States 4 Global 38
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39999
Advantage
60
Creative Peptides
Tel
Email
info@creative-peptides.com
Country
United States
ProdList
6083
Advantage
56
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29661
Advantage
68
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303;
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4801
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
7617
Advantage
58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19654
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471;
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58

1228078-65-6, PAR-4 Agonist Peptide, amide TFARelated Search:


  • PAR-4 Agonist Peptide, amide TFA
  • AY-NH2 TFA)
  • PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA
  • PAR-4-AP (TFA)
  • Thrombin receptors,PAR4 Agonist Peptide, amide TFA,Protease Activated Receptor (PAR),inhibit,AY-NH2,PAR-4 Agonist Peptide, amide,Inhibitor,PAR 4 Agonist Peptide, amide TFA
  • PAR-4 Agonist Peptide, amide TFA, 10 mM in DMSO
  • Ala-Tyr-Pro-Gly-Lys-Phe-NH<sub>2</sub> trifluoroacetate salt
  • (S)-1-(L-Alanyl-L-tyrosyl)-N-(2-(((S)-6-amino-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-1-oxohexan-2-yl)amino)-2-oxoethyl)pyrrolidine-2-carboxamide 2,2,2-trifluoroacetate
  • 1228078-65-6