ChemicalBook > CAS DataBase List > HOOCCH2O-PEG4-CH2CH2COOtBu
HOOCCH2O-PEG4-CH2CH2COOtBu
- Product Name
- HOOCCH2O-PEG4-CH2CH2COOtBu
- CAS No.
- 2304558-22-1
- Chemical Name
- HOOCCH2O-PEG4-CH2CH2COOtBu
- Synonyms
- Acid-C1-PEG5-Boc;HOOCCH2O-PEG4-CH2CH2COOtBu;t-butyl ester-PEG5-CH2COOH;PROTAC Linkers,Acid C1 PEG5 Boc,inhibit,Inhibitor,Acid-C-1-PEG5-Boc,AcidC1PEG5Boc;2-[2-[2-[2-[2-(3-tert-butoxy-3-oxo-propoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid;HOOCCH2O-PEG4-CH2CH2COOtBu/20,20-Dimethyl-18-oxo-3,6,9,12,15,19-hexaoxahenicosan-1-oic acid
- CBNumber
- CB45428061
- Molecular Formula
- C17H32O9
- Formula Weight
- 380.43
- MOL File
- 2304558-22-1.mol
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HOOCCH2O-PEG4-CH2CH2COOtBu Property
- Boiling point:
- 483.4±40.0 °C(Predicted)
- Density
- 1.121±0.06 g/cm3(Predicted)
- solubility
- Soluble in Water, DMSO, DMF
- pka
- 3.39±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
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N-Bromosuccinimide Price
BroadPharm
- Product number
- BP-24282
- Product name
- t-butylester-PEG5-CH2COOH
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-24282
- Product name
- t-butylester-PEG5-CH2COOH
- Purity
- 98%
- Packaging
- 250mg
- Price
- $650
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-24282
- Product name
- t-butylester-PEG5-CH2COOH
- Purity
- 98%
- Packaging
- 500mg
- Price
- $970
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-24282
- Product name
- t-butylester-PEG5-CH2COOH
- Purity
- 98%
- Packaging
- 1g
- Price
- $1700
- Updated
- 2021/12/16
Acrotein
- Product number
- B-1368
- Product name
- HOOCCH2O-PEG4-CH2CH2COOtBu
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $220
- Updated
- 2021/12/16
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HOOCCH2O-PEG4-CH2CH2COOtBu Chemical Properties,Usage,Production
Description
t-butyl ester-PEG5-CH2COOH is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Acid-C1-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
HOOCCH2O-PEG4-CH2CH2COOtBu Preparation Products And Raw materials
Raw materials
Preparation Products
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HOOCCH2O-PEG4-CH2CH2COOtBu Suppliers
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