6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
- Product Name
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
- CAS No.
- 2068065-16-5
- Chemical Name
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
- Synonyms
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-hydroxy-
- CBNumber
- CB45441866
- Molecular Formula
- C8H4BrN3O
- Formula Weight
- 238.04
- MOL File
- 2068065-16-5.mol
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Property
- Density
- 1.88±0.1 g/cm3(Predicted)
- pka
- 6.41±0.30(Predicted)
- InChI
- InChI=1S/C8H4BrN3O/c9-6-1-7(13)8-5(2-10)3-11-12(8)4-6/h1,3-4,13H
- InChIKey
- IFUVDUFAFVWZOT-UHFFFAOYSA-N
- SMILES
- C12=C(C#N)C=NN1C=C(Br)C=C2O
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Chemical Properties,Usage,Production
Uses
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile is a pharmaceutical intermediate used in the preparation of Selpercatinib, an FDA-approved drug for the treatment of RET-positive advanced non-small cell lung cancer (NSCLC), thyroid cancer and certain other cancers
Synthesis
At room temperature, add 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (50g, 198.36mmol) and water (16.5mL, 916mmol) in a 1L single-neck flask in sequence, Sodium hydroxide (16.03g, 396.8mmol), DMA (500mL), stirred at room temperature for 5min, then transferred to 0°C, slowly added dodecanethiol (97mL, 397mmol), after the addition, the reaction was moved to 45°C overnight. Pour the reaction solution into 3L ice water, slowly add saturated citric acid water to adjust the PH=5, stir for half an hour, and then stand still filter, wash the filter cake with water and petroleum ether several times, and dry at 60°C to obtain 44.1g of yellow solid 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile (6-Bromo-4-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile).
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Suppliers
- Tel
- 0592-7828678 18050056030
- Fax
- 0592-7828678
- yezhaobao@yfpharm.com
- Country
- China
- ProdList
- 72
- Advantage
- 58
- Tel
- 512-68236360 13912645265
- lxm@guide-chemicals.com
- Country
- China
- ProdList
- 236
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44700
- Advantage
- 61
- Tel
- 0512-68780025,68780026 18962125825
- sales@ryanchem.com
- Country
- China
- ProdList
- 161
- Advantage
- 62
- Tel
- 3429815786 13301662590
- Fax
- +86-21-51619052
- sales@atkchemical.com
- Country
- China
- ProdList
- 10004
- Advantage
- 55
- Tel
- 0571-86828652 18857119830
- Fax
- 0571-83522824
- sales@chemtrue-bio.com
- Country
- China
- ProdList
- 314
- Advantage
- 58
- Tel
- 025-66113011 13155353615
- Fax
- (7)02557626880
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15396
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19994
- Advantage
- 58
- Tel
- 13021512891
- Fax
- QQ:3554193828
- sales04@chemfish.com
- Country
- China
- ProdList
- 6633
- Advantage
- 58
- Tel
- 18201884268
- magean83@163.com
- Country
- China
- ProdList
- 1252
- Advantage
- 58
- Tel
- 86-21-50800795
- info@shochem.com
- Country
- CHINA
- ProdList
- 288
- Advantage
- 58
- Tel
- 021-13773155751 19901447308
- 260924549@qq.com
- Country
- China
- ProdList
- 8755
- Advantage
- 58
- Tel
- 021-58461859 15821823057
- service@aiviche.com
- Country
- China
- ProdList
- 49323
- Advantage
- 58
- Tel
- 0510-83591909 18018392058
- Fax
- 0510-83591909
- info@enbridgepharm.com
- Country
- China
- ProdList
- 180
- Advantage
- 58
- Tel
- 17625585511
- Fax
- qq:1580084073
- 1580084073@qq.com
- Country
- China
- ProdList
- 473
- Advantage
- 58
- Tel
- 0371-0371-55135753 18003832934
- Fax
- QQ:2853979818
- 2853979818@qq.com
- Country
- China
- ProdList
- 9989
- Advantage
- 58
- Tel
- 17280940401
- huiyu_bio@126.com
- Country
- China
- ProdList
- 762
- Advantage
- 58
- Tel
- 027-027-59207852 13308628970
- Fax
- QQ:2779667926
- buy@fortunachem.com
- Country
- China
- ProdList
- 2645
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 39997
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- product02@bidepharm.com
- Country
- China
- ProdList
- 63720
- Advantage
- 58
- Tel
- 0371-65741762
- Fax
- QQ:2860768577
- sales@hasunny.com
- Country
- China
- ProdList
- 2380
- Advantage
- 58
- Tel
- 182-3786-0830 19913859908
- 290833579@qq.com
- Country
- China
- ProdList
- 534
- Advantage
- 58
- Tel
- 13971275651
- sales@whyxpharma.com
- Country
- China
- ProdList
- 3784
- Advantage
- 58
- Tel
- 400-618-1121
- Fax
- 400-618-1121
- sales@townyuan.com
- Country
- China
- ProdList
- 2984
- Advantage
- 58
- Tel
- 0731-85567275 13517472705
- tokyo@chemfish.com
- Country
- China
- ProdList
- 629
- Advantage
- 58
- Tel
- 4000255188 13327728092
- gao_ning@pharmablock.com
- Country
- China
- ProdList
- 9699
- Advantage
- 58
- Tel
- 13053322091 13053322091
- admin@mopaikeji.com
- Country
- China
- ProdList
- 10974
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- syeu@accelachem.com
- Country
- China
- ProdList
- 11712
- Advantage
- 58
- Tel
- 18055651951
- 2272561977@qq.com
- Country
- China
- ProdList
- 507
- Advantage
- 58
- Tel
- 021-13621551597 19975051755
- 260924549@qq.com
- Country
- China
- ProdList
- 6455
- Advantage
- 58
- Tel
- 029-81122149 13992773979
- 1088@dideu.com
- Country
- China
- ProdList
- 2730
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32686
- Advantage
- 60
- Tel
- +8618050056030
- yezhaobao@yfpharm.com
- Country
- China
- ProdList
- 20
- Advantage
- 58
- Tel
- +86-512-68323967 +86-18015559028
- sales1@artkmedchem.com
- Country
- China
- ProdList
- 39009
- Advantage
- 58
- Tel
- +86-371-86557731 +86-13613820652
- Fax
- 86-0371-86557731
- info@fdachem.com
- Country
- China
- ProdList
- 18219
- Advantage
- 58
- Tel
- +8619950309693
- diane@biosynce.com
- Country
- China
- ProdList
- 4874
- Advantage
- 58
- Tel
- +86-0533-2185556 +8617865335152
- Mandy@hangyubiotech.com
- Country
- China
- ProdList
- 11013
- Advantage
- 58
- Tel
- +86-0757-22239986 +86-18029359586
- sales@mkmeditech.com
- Country
- China
- ProdList
- 1134
- Advantage
- 58
- Tel
- +undefined18958062155
- sales@zjgoldpharm.com
- Country
- China
- ProdList
- 5905
- Advantage
- 58
- Tel
- +86-0371-63689365 +8618638391208
- sales@aochuangchem.com
- Country
- China
- ProdList
- 9425
- Advantage
- 58
- Tel
- +86-512-68780025 +8618962125825
- Fax
- 0512-68780025-8004
- sales@ryanchem.com
- Country
- China
- ProdList
- 137
- Advantage
- 58
- Tel
- +8613812269233
- Fax
- 0510-83591909
- tinayang@enbridgepharm.com
- Country
- China
- ProdList
- 303
- Advantage
- 58
View Lastest Price from 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile manufacturers
- Product
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 2068065-16-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500Kilogram/Month
- Release date
- 2024-05-14
- Product
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 2068065-16-5
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 2068065-16-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08