ChemicalBook > CAS DataBase List > S29434
S29434
- Product Name
- S29434
- CAS No.
- 874484-20-5
- Chemical Name
- S29434
- Synonyms
- S29434;S29434, 10 mM in DMSO;N-(2-(2-Methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl)furan-2-carboxamide;2-Furancarboxamide, N-[2-(2-methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl]-;cell-permeable,inhibit,selective,S 29434,HepG2,mice,NMDPEF,S-29434,ROS,Autophagy,S29434,Inhibitor,memory;N-(2-{5-methoxy-1,6,11-triazatetracyclo[7.7.0.02,?.01?,1?]hexadeca-2(7),3,5,8,10(15),11,13-heptaen-8-yl}ethyl)furan-2-carboxamide
- CBNumber
- CB45476532
- Molecular Formula
- C21H18N4O3
- Formula Weight
- 374.39
- MOL File
- 874484-20-5.mol
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S29434 Property
- Boiling point:
- 695.0±55.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 19.29 mg/mL (51.52 mM); Water: < 0.1 mg/mL (insoluble)
- pka
- 13.92±0.46(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
DC Chemicals
- Product number
- DC12622
- Product name
- S29434
- Purity
- >98%
- Packaging
- 100mg
- Price
- $950
- Updated
- 2021/12/16
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S29434 Chemical Properties,Usage,Production
Uses
S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production[1].
in vivo
S29434 (1 and 15 mg/kg; i.p. once) affects object recognition memory in vivo[1].
| Animal Model: | CH3 wild-type mice[1] |
| Dosage: | 1 and 15 mg/kg |
| Administration: | Intraperitoneal injection; 1 and 15 mg/kg once |
| Result: | Positively affected memory by inhibiting QR2. |
References
[1] Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285. DOI:10.1124/mol.118.114231
S29434 Preparation Products And Raw materials
Raw materials
Preparation Products
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