CCB02
- Product Name
- CCB02
- CAS No.
- 2100864-57-9
- Chemical Name
- CCB02
- Synonyms
- CCB02;CCB-02,CCB02;Benzo[b][1,6]naphthyridine-4-carbonitrile, 3-methoxy-
- CBNumber
- CB45540358
- Molecular Formula
- C14H9N3O
- Formula Weight
- 235.24
- MOL File
- 2100864-57-9.mol
CCB02 Property
- Boiling point:
- 467.2±25.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 25 mg/mL (106.27 mM)
- pka
- 2.53±0.30(Predicted)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- CS-0081987
- Product name
- CCB02
- Purity
- 99.77%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0081987
- Product name
- CCB02
- Purity
- 99.77%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0081987
- Product name
- CCB02
- Purity
- 99.77%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0081987
- Product name
- CCB02
- Purity
- 99.77%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
CCB02 Chemical Properties,Usage,Production
Description
CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM, and shows potent anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora A, Plk1, Plk2, CDK2, and CHK1[1].
CCB02 is a selective CPAP-tubulin interaction inhibitor, binding to tubulin and competing for the CPAP binding site of β-tubulin, with an IC50 of 689 nM. CCB02 perturbs CPAP PN2-3-tubulin interaction with an IC50 of 0.441 μM in a PN2-3 CPAP-GST pull-down assay[1].CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora A, Plk1, Plk2, CDK2, and CHK1[1].CCB02 inhibits the proliferation of cancer cells with extra centrosomes, IC50s are 0.86-2.9 μM. CCB02 activates spindle assembly checkpoint, induces PCM proteins recruitment to centrosomes, and enhances microtubule nucleation activities of centrosomes[1].
CCB02 (30 mg/kg, p.o. daily) shows potent anti-tumor effect in nude mice bearing subcutaneous human lung (H1975T790M cells) tumor xenografts. CCB02 also suppresses MDA-MB-231 cell migration and cuases multipolar mitosis in mouse xenografts[1].
References
[1]. Mariappan A, et al. Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells. EMBO J. 2019 Jan 15;38(2). pii: e99876.
CCB02 Preparation Products And Raw materials
Raw materials
Preparation Products
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