ChemicalBook > CAS DataBase List > JWG-071

JWG-071

Product Name
JWG-071
CAS No.
2250323-50-1
Chemical Name
JWG-071
Synonyms
JWG-071;JWG 071,JWG071;JWG-071, 10 mM in DMSO;11-(sec-Butyl)-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one;6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl-11-(1-methylpropyl)-
CBNumber
CB45544730
Molecular Formula
C34H44N8O3
Formula Weight
612.77
MOL File
2250323-50-1.mol
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JWG-071 Property

Boiling point:
801.7±75.0 °C(Predicted)
Density 
1.238±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
8.14±0.42(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2541
Product name
JWG-071
Purity
≥98% (HPLC)
Packaging
5MG
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2541
Product name
JWG-071
Purity
≥98% (HPLC)
Packaging
25MG
Price
$380
Updated
2024/03/01
ChemScene
Product number
CS-8155
Product name
JWG-071
Purity
98.55%
Packaging
5mg
Price
$708
Updated
2021/12/16
DC Chemicals
Product number
020507
Product name
JWG-071
Packaging
001
Price
$350
Updated
2021/12/16
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JWG-071 Chemical Properties,Usage,Production

Biological Activity

JWG-071 is the first reported ERK5 kinase-selective chemical probe which can increases ERK5 activity and BRD4 selectivity. It will be a much-needed chemical probe for deconvoluted ERK5 and BRD4 pharmacology.

in vitro

JWG-071 inhibits ERK5 and LRRK2 with IC 50 of 88 and 109 nM, respectively.

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target

ERK5

88 nM (IC 50 )

JWG-071 Preparation Products And Raw materials

Raw materials

Preparation Products

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JWG-071 Suppliers

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2250323-50-1, JWG-071Related Search:


  • JWG-071
  • 6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl-11-(1-methylpropyl)-
  • JWG 071,JWG071
  • 11-(sec-Butyl)-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one
  • JWG-071, 10 mM in DMSO
  • 2250323-50-1
  • C34H44N8O3