(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)

Product Name: (5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)
CAS No.: 2374856-75-2
Chemical Name: (5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)
Synonyms: Evixapodlin;PD-1/PD-L1-IN 7;Evixapodlin, 10 mM in DMSO;(5S,5'S)-5,5'-((((5,5'-(2,2'-DICHLORO-[1,1'-BIPHENYL]-3,3'-DIYL)BIS(3-METHOXYPYRAZINE-5,2-DIYL))BIS(;2-Pyrrolidinone, 5,5'-[(2,2'-dichloro[1,1'-biphenyl]-3,3'-diyl)bis[(3-methoxy-5,2-pyrazinediyl)methyleneiminomethylene]]bis-, (5S,5'S)-;(5S,5'S)-5,5'-(((((2,2'-Dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one);(5S,5'S)-5,5'-(((((2,2'-Dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one);(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)
CBNumber: CB45590818
Molecular Formula: C34H36Cl2N8O4
Formula Weight: 691.61
MOL File: 2374856-75-2.mol

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(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one) Property

Boiling point:: 817.1±65.0 °C(Predicted)
Density: 1.310±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (72.30 mM; Need ultrasonic)
pka: 15.81±0.40(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0148224
Product name: PD-1/PD-L1-IN7
Purity: 98.48%
Packaging: 5mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0148224
Product name: PD-1/PD-L1-IN7
Purity: 98.48%
Packaging: 10mg
Price: $800
Updated: 2021/12/16

ChemScene

Product number: CS-0148224
Product name: PD-1/PD-L1-IN7
Purity: 98.48%
Packaging: 25mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0148224
Product name: PD-1/PD-L1-IN7
Purity: 98.48%
Packaging: 50mg
Price: $2550
Updated: 2021/12/16

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(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one) Chemical Properties,Usage,Production

Uses

Evixapodlin (GS-4224) is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. Evixapodlin has anticancer and antiviral functions[1].

in vivo

Evixapodlin (Compound 139; 10-50 mg/kg; intraperitoneal injection, daily, for 6 days) treatment shows >90% PD-L1 target occupancy (TO) on the tumor cells. Evixapodlin significantly inhibits tumor growth in a human PD-L1 expressing MC38 mouse colorectal tumor model^[1].

Animal Model:	Female C57BL/6 mice injected with MC38 tumor cells^[1]
Dosage:	10 mg/kg, 25 mg/kg, and 50 mg/kg
Administration:	Intraperitoneal injection, daily, for 6 days
Result:	Showed greater than 90% TO on the tumors and inhibited tumor growth in vivo.

References

[1] Evangelos Aktoudianakis, et al. Pd-1/pd-l1 inhibitors. WO2019160882A1.

(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one) Preparation Products And Raw materials

Raw materials

Preparation Products

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(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one) Suppliers

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2374856-75-2, (5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)Related Search:

(5S,5'S)-5,5'-((((5,5'-(2,2'-dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)

(5S,5'S)-5,5'-((((5,5'-(2,2'-DICHLORO-[1,1'-BIPHENYL]-3,3'-DIYL)BIS(3-METHOXYPYRAZINE-5,2-DIYL))BIS(

2-Pyrrolidinone, 5,5'-[(2,2'-dichloro[1,1'-biphenyl]-3,3'-diyl)bis[(3-methoxy-5,2-pyrazinediyl)methyleneiminomethylene]]bis-, (5S,5'S)-

Evixapodlin

PD-1/PD-L1-IN 7

(5S,5'S)-5,5'-(((((2,2'-Dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)

Evixapodlin, 10 mM in DMSO

(5S,5'S)-5,5'-(((((2,2'-Dichloro-[1,1'-biphenyl]-3,3'-diyl)bis(3-methoxypyrazine-5,2-diyl))bis(methylene))bis(azanediyl))bis(methylene))bis(pyrrolidin-2-one)

2374856-75-2

APIs