ChemicalBook > CAS DataBase List > 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

Product Name
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
CAS No.
1158264-69-7
Chemical Name
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
Synonyms
hydrochloride - [A81477];Lenalidomide-5-aminomethyl hydrochloride;3-[5-(Aminomethyl)-1-oxo-2-isoindolinyl]piperidine-2,6-dione Hydrochloride;3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride;3-[5-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride;3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride , Lenalidomide-5-aminomethyl HCl
CBNumber
CB45708178
Molecular Formula
C14H16ClN3O3
Formula Weight
309.75
MOL File
1158264-69-7.mol
More
Less

3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Property

storage temp. 
-20°C, stored under nitrogen, away from moisture
solubility 
DMSO : 16.67 mg/mL (53.82 mM; ultrasonic and warming and heat to 60°C)
form 
Solid
color 
Off-white to light yellow
InChI
InChI=1S/C14H15N3O3.ClH/c15-6-8-1-2-10-9(5-8)7-17(14(10)20)11-3-4-12(18)16-13(11)19;/h1-2,5,11H,3-4,6-7,15H2,(H,16,18,19);1H
InChIKey
XTILEMYXOZKSFJ-UHFFFAOYSA-N
SMILES
O=C1C2=CC=C(CN)C=C2CN1C1CCC(=O)NC1=O.Cl
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

1Pluschem
Product number
1P01JY9O
Product name
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
Purity
95%
Packaging
100mg
Price
$384
Updated
2021/12/16
1Pluschem
Product number
1P01JY9O
Product name
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
Purity
95%
Packaging
250mg
Price
$760
Updated
2021/12/16
DC Chemicals
Product number
027683
Product name
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dionehydrochloride
Packaging
002
Price
$1200
Updated
2021/12/16
1Pluschem
Product number
1P01JY9O
Product name
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
Purity
95%
Packaging
1g
Price
$1640
Updated
2021/12/16
DC Chemicals
Product number
027683
Product name
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dionehydrochloride
Packaging
003
Price
$2700
Updated
2021/12/16
More
Less

3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Chemical Properties,Usage,Production

Description

3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride is used in the recruitment of the cereblon protein and used as a PROTAC linker.

Uses

Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]

IC 50

Cereblon

References

[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Suppliers

China 54 United States 2 Global 56
Shanghai Fulaiyide Pharmaceutical Technology Co., Ltd
Tel
19033008971 13182942551 19331071838
Email
wang666xt@163.com
Country
China
ProdList
428
Advantage
58
Anhui Shuoyuan Pharmaceutical Technology R&D Co.,Ltd
Tel
05558228005 18151793555
Email
413315120@qq.com
Country
China
ProdList
170
Advantage
58
Abosyn
Tel
0512-69561983 13914027025
Email
he_qf@medinoah.com
Country
China
ProdList
3001
Advantage
58
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7471
Advantage
65
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4769
Advantage
55
Lianyungang TengFa Biological Technology Co. Ltd
Tel
0518-85475186 18705131893
Fax
0518-85475186
Email
wang666xt@163.com
Country
China
ProdList
351
Advantage
55
Feihe Pharmatech Co.,Ltd
Tel
021-33926058 18030239092
Fax
+86-21-33926078
Email
xuxin@fenhechem.com
Country
China
ProdList
159
Advantage
55
shandong XuanHong Pharmaceutical Technology Co.,Ltd
Tel
+86-0531-88801869 15090917080
Fax
0531-88801867
Email
sciencechem@163.com
Country
China
ProdList
292
Advantage
55
LinkChem Technology Co., Ltd.
Tel
021-58950110 13124863828
Fax
021-20922272
Email
sales@linkchem.cn
Country
China
ProdList
2998
Advantage
58
Jiaxing Deyi Chemical Co., Ltd.
Tel
86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8596
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15083
Advantage
58
Nanjing Daqin Pharmaceutical Technology Co., Ltd.
Tel
025-025-58470199 18351831988
Fax
025-58470199
Email
sales@daqinpharma.cn
Country
China
ProdList
312
Advantage
58
SuZhou Medinoah Co.,LTD.
Tel
0512-69561983 13914027025
Fax
0512-69561982
Email
zhang_q@medinoah.com
Country
China
ProdList
3811
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
Shanghai Hongle Biotechnology Co., Ltd
Tel
021-56145923; 4001631568
Email
sales@honglebiotech.com
Country
China
ProdList
920
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55055611 18137792234
Fax
QQ：3002694073
Email
3002694073@qq.com
Country
China
ProdList
9987
Advantage
58
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1615
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Jinan Ruisi Pharmaceutical Technology Co., LTD
Tel
0531-0531-69900633 19963472814
Email
changyuan20@163.com
Country
China
ProdList
2742
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Shanghai Xiushi Biomedical Co., LTD
Tel
15002184385 15021598081 15002184385
Email
product001@xiushipharm.com
Country
China
ProdList
4719
Advantage
58
Shanghai Zhidao Biotechnology Co., Ltd
Tel
18156046398
Fax
50836592@qq.com
Email
50836592@qq.com
Country
China
ProdList
116
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81124267 17392282731
Fax
029-88380327
Email
1073@dideu.com
Country
China
ProdList
9992
Advantage
58
Nanjing Yili Biotechnology Co., Ltd.
Tel
15380789538
Email
2885743537@qq.com
Country
China
ProdList
8205
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Tianjin Kaimu Chemical Technology Co., LTD
Tel
13116033142 13116033142
Email
kaimuchem@163.com
Country
China
ProdList
500
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-80514535 19917294565
Email
et@chemextension.com
Country
China
ProdList
5061
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054;
Email
trendseenbio@gmail.com
Country
China
ProdList
9069
Advantage
58
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 086-15871494362 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
6762
Advantage
58
Shanghai Easy CDMO Co.,Ltd
Tel
021-61734564 13854185395;
Email
info@easycdmo.com
Country
China
ProdList
10024
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
999
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58
PharmaBlock Sciences (Nanjing), Inc.
Tel
4000255188
Email
sales@pharmablock.com
Country
China
ProdList
7268
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29995
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
syeu@accelachem.com
Country
China
ProdList
11015
Advantage
58
Jilin Chinese Academy of Sciences-yanshen Technology
Tel
18143011203
Email
ET-market@chemextension.com
Country
China
ProdList
32050
Advantage
58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
Tel
17316404525 17316404525
Email
209533805@qq.com
Country
China
ProdList
9766
Advantage
58
Shandong XuanHong Biopharmaceutical Co., Ltd.
Tel
0531-88801869 15090917080
Email
2955128025@qq.com
Country
China
ProdList
138
Advantage
58
Henan Mengtai Pharmaceutical Technology Co., Ltd
Tel
176345344 7 17634854698
Email
1959525201@qq.com
Country
China
ProdList
10000
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Suzhou Derivative Biotechnology Co., Ltd.
Tel
13915541704
Email
2436368162@qq.com
Country
China
ProdList
554
Advantage
58
Shanghai Yaoheping Biopharmaceutical Technology Co., Ltd
Tel
021-57540919 13120888836
Email
lily@yhp-biomedicine.com
Country
China
ProdList
8254
Advantage
58
Zibo Hangyu Biotechnology Development Co., Ltd
Tel
+86-0533-2185556 +8615965530500
Email
nickzhang@hangyubiotech.com
Country
China
ProdList
8510
Advantage
58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd
Tel
+8618235132063
Email
sales@tihondan.com
Country
China
ProdList
3767
Advantage
58
Suzhou ARTK Medchem Co., Ltd.
Tel
+86-512-68323658 +86-18168183658
Email
sales1@artkmedchem.com
Country
China
ProdList
39002
Advantage
58
Wuhan Jingkang en Biomedical Technology Co., Ltd
Tel
+8613720134139
Email
orders@jknbiochem.com
Country
China
ProdList
5221
Advantage
58

1158264-69-7, 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochlorideRelated Search:

3-(4-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride

  • 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
  • 3-[5-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride
  • Lenalidomide-5-aminomethyl hydrochloride
  • 3-[5-(Aminomethyl)-1-oxo-2-isoindolinyl]piperidine-2,6-dione Hydrochloride
  • 3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride , Lenalidomide-5-aminomethyl HCl
  • hydrochloride - [A81477]
  • 1158264-69-7
  • E3 ligase Ligan