Tubulysin I
- Product Name
- Tubulysin I
- CAS No.
- 799822-10-9
- Chemical Name
- Tubulysin I
- Synonyms
- Tubulysin I;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-3-[[(acetyloxy)methyl][(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl]amino]-4-methylpentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
- CBNumber
- CB45821200
- Molecular Formula
- C40H59N5O10S
- Formula Weight
- 801.99
- MOL File
- 799822-10-9.mol
Tubulysin I Property
- Boiling point:
- 967.4±65.0 °C(Predicted)
- Density
- 1.222±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 4.52±0.23(Predicted)
Tubulysin I Chemical Properties,Usage,Production
Uses
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].
References
[1] Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. DOI:10.1002/anie.200906828
[2] Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. DOI:10.1016/j.bmcl.2011.09.041