ChemicalBook > CAS DataBase List > NF-56-EJ40

NF-56-EJ40

Product Name
NF-56-EJ40
CAS No.
2380230-73-7
Chemical Name
NF-56-EJ40
Synonyms
NF-56-EJ40;NF-56-EJ40, 10 mM in DMSO;NF56EJ40,inhibit,NF-56-EJ-40,NF 56 EJ40,GPR91,SUCNR1,Inhibitor;2-(2-(4'-((4-Methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid;Benzeneacetic acid, 2-[[[4'-[(4-methyl-1-piperazinyl)methyl][1,1'-biphenyl]-3-yl]carbonyl]amino]-
CBNumber
CB45848962
Molecular Formula
C27H29N3O3
Formula Weight
443.54
MOL File
2380230-73-7.mol
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NF-56-EJ40 Property

Boiling point:
586.6±50.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 5 mg/mL (11.27 mM); Water: 4.55 mg/mL (10.26 mM; ultrasonic and adjust pH to 9 with NaOH)
pka
4.14±0.10(Predicted)
form 
Solid
color 
Off-white to gray
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3338
Product name
NF-56-EJ40
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$117
Updated
2026/04/30
Sigma-Aldrich
Product number
SML3338
Product name
NF-56-EJ40
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$470
Updated
2026/04/30
ChemScene
Product number
CS-0106010
Product name
NF-56-EJ40
Purity
99.92%
Packaging
5mg
Price
$108
Updated
2026/06/04
ChemScene
Product number
CS-0106010
Product name
NF-56-EJ40
Purity
99.92%
Packaging
10mg
Price
$184
Updated
2026/06/04
ChemScene
Product number
CS-0106010
Product name
NF-56-EJ40
Purity
99.92%
Packaging
25mg
Price
$433
Updated
2026/06/04
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NF-56-EJ40 Chemical Properties,Usage,Production

Uses

NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM[1].

Biological Activity

NF-56-EJ40 is a potent, high affinity and highly selective antagonist of human SUCNR1 (GPR91) with IC50 of 25 nM and Ki of 33.5 nM, with little activity against rat SUCNR1. It has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.

in vitro

NF-56-EJ40 is bound deep inside the hydrophobic pocket, with the acid group coordinated by the hydroxyl groups of the conserved residues Y83 2.64 and Y30 1.39 on one side, and R281 7.39 on the other side. The conserved E18 1.27 is predicted to form an additional hydrogen bond to the piperazine ring of NF-56-EJ40. E22 1.31 and N274 7.32 in human SUCNR1 are replaced by K181.31 and K269 7.32 in rat SUCNR1. These two amino acid exchanges could prevent the binding of NF-56-EJ40 to rat SUCNR1 owing to steric hindrance. Radioligand-binding studies with human SUCNR1 showed partial agreement with our homology model: the Y30 1.39 F mutant of human SUCNR1, showing reduced binding of NF-56-EJ40. Similar effects are observed with the E18 1.27 K and E18 1.27 R mutants, probably owing to steric clashes of the Lys and Arg residues with NF-56 -EJ40 and the loss of a h ydrogen bond to its piperazine ring.
Human SUCNR1 residues are introduced into rat SUCNR1 to form the double mutant K18 1.31 E/K269 7.32 N (hereafter denoted humanized rat SUCNR1) ( K i of 17.4 nM and 33.5 nM for human and humanized rat SUCNR1, respectively). NF-56-EJ40 increases the thermal stability of both humanized rat SUCNR1 and human SUCNR1, but not that of rat SUCNR1.

target

SUCNR1 (GPR91)

References

[1] Haffke M, et al. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 2019 Oct;574(7779):581-585. DOI:10.1038/s41586-019-1663-8

NF-56-EJ40 Preparation Products And Raw materials

Raw materials

Preparation Products

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NF-56-EJ40 Suppliers

China 27 United States 5 Global 32
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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9920
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4839
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
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China
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89686
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Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
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China
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9705
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
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United States
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Shanghai Dongyang Biotechnology Co., Ltd.
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0512-13601744364 13601744364
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chemsharker@126.com
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China
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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Shanghai hongqu biomedical technology co. LTD
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88888888888
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hongquchem@qq.com
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China
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Zhejiang Huida Biotech Co., LTD
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89903882 18341477883
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luanbowen@huidabiotech.com
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China
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2380230-73-7, NF-56-EJ40Related Search:


  • NF-56-EJ40
  • NF56EJ40,inhibit,NF-56-EJ-40,NF 56 EJ40,GPR91,SUCNR1,Inhibitor
  • Benzeneacetic acid, 2-[[[4'-[(4-methyl-1-piperazinyl)methyl][1,1'-biphenyl]-3-yl]carbonyl]amino]-
  • 2-(2-(4'-((4-Methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-3-carboxamido)phenyl)acetic acid
  • NF-56-EJ40, 10 mM in DMSO
  • 2380230-73-7