Befotertinib

Product Name: Befotertinib
CAS No.: 1835667-63-4
Chemical Name: Befotertinib
Synonyms: CPD0557;Befotertinib;Befotertinib (D-0316);Befotertinib, 10 mM in DMSO;lung,Epidermal growth factor receptor,D0316,D 0316,ErbB-1,Inhibitor,HER1,inhibit,cancer,EGFR,kinase,tyrosine,non-small,NSCLC;N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-[1-(2,2,2-trifluoroethyl)-1H-indol-3-yl]-2-pyrimidinyl]amino]phenyl]-
CBNumber: CB45849176
Molecular Formula: C29H32F3N7O2
Formula Weight: 567.61
MOL File: 1835667-63-4.mol

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Befotertinib Property

Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 62.5 mg/mL (110.11 mM; ultrasonic and warming and heat to 60°C)
pka: 12.68±0.70(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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Befotertinib Chemical Properties,Usage,Production

Uses

Befotertinib (D-0316) is the third-generation EGFR tyrosine kinase inhibitor. Befotertinib can be used for the research of EGFR T790M-positive non-small cell lung cancer (NSCLC)[1].

References

[1] Nagasaka M, et, al. Beyond Osimertinib: The Development of Third-Generation EGFR Tyrosine Kinase Inhibitors For Advanced EGFR+ NSCLC. J Thorac Oncol. 2021 May;16(5):740-763. DOI:10.1016/j.jtho.2020.11.028

Befotertinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Befotertinib Suppliers

China 28 United States 3 Global 31

BOC Sciences

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1835667-63-4, BefotertinibRelated Search:

N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-[1-(2,2,2-trifluoroethyl)-1H-indol-3-yl]-2-pyrimidinyl]amino]phenyl]-

Befotertinib

CPD0557

lung,Epidermal growth factor receptor,D0316,D 0316,ErbB-1,Inhibitor,HER1,inhibit,cancer,EGFR,kinase,tyrosine,non-small,NSCLC

Befotertinib, 10 mM in DMSO

Befotertinib (D-0316)

1835667-63-4

C29H32F3N7O2