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BIIB068

Product Name
BIIB068
CAS No.
1798787-27-5
Chemical Name
BIIB068
Synonyms
BIIB068;BIIB-068;BIIB068, 10 mM in DMSO;3-Isopropoxy-N-(2-methyl-4-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)benzyl)azetidine-1-carboxamide;N-[(2-methyl-4-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}phenyl)methyl]-3-(propan-2-yloxy)azetidine-1-carboxamide;1-Azetidinecarboxamide, 3-(1-methylethoxy)-N-[[2-methyl-4-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]phenyl]methyl]-;ADME,inhibit,FcγR,Autoimmune,Bruton tyrosine kinase,TNFα,BIIB 068,ROS,Inhibitor,reversible,Btk,anti-IgD,phosphorylation,BIIB068,anti-IgM,BIIB-068
CBNumber
CB45853001
Molecular Formula
C23H29N7O2
Formula Weight
435.52
MOL File
1798787-27-5.mol
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BIIB068 Property

Density 
1.30±0.1 g/cm3(Predicted)
solubility 
DMSO:30.63(Max Conc. mg/mL);70.33(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.46(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);68.88(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);22.96(Max Conc. mM)
form 
A crystalline solid
pka
13.40±0.40(Predicted)
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0133440
Product name
BIIB068
Purity
99.20%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0133440
Product name
BIIB068
Purity
99.20%
Packaging
10mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0133440
Product name
BIIB068
Purity
99.20%
Packaging
25mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0133440
Product name
BIIB068
Purity
99.20%
Packaging
50mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0133440
Product name
BIIB068
Purity
99.20%
Packaging
100mg
Price
$1650
Updated
2021/12/16
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BIIB068 Chemical Properties,Usage,Production

Uses

BIIB068 is a potent, selective, reversible and orally active BTK inhibitor with an IC50 of 1 nM and a Kd of 0.3 nM. BIIB068 shows more >400-fold selective for BTK than other kinases. BIIB068 has the potential for autoimmune diseases research[1].

in vivo

BIIB068 (compound 1) is stable in the plasma of mouse, rat, beagle dog, and cynomolgus monkey (>95% parent compound remaining after 6 hours of incubation)[1].
BIIB068 (compound 1) exhibits good drug-like properties (LLE = 5) which results in low in vivo clearance (CL %Qh = 6) and moderate oral bioavailability (%F = 48) when dosed in rats. BIIB068 (5 mg/kg; po) treatment shows the T1/2 of 1.2 hours, 2.1 hours and 0.9 hour for rats, dog and cynomolgus monkey, respectively. BIIB068 shows acceptable ADME (absorption, distribution, metabolism, and excretion) properties[1].

References

[1] Bin Ma, Tonika Bohnert, et al. Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases. J Med Chem. 2020 Jul 22. DOI:10.1021/acs.jmedchem.0c00702

BIIB068 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIIB068 Suppliers

China 39 United States 4 Global 43
BOC Sciences
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1-631-485-4226; 16314854226
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info@bocsci.com
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United States
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Shanghai XingMo Biotechnology Co., Ltd.
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+86 13524779951; 13524779951
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QQ: 2075692521
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2075692521@qq.com
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China
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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info@efebio.com
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China
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AgileBioChem Co., Ltd.
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18055517827
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sales@agilebiochem.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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Shanghai SuperLan Chemcial Technique Centre
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0-2022843681 15618226720
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+86-21-51601218
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chaolaichem@foxmail.com
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China
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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32435
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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sales@chemegen.com
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China
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Shenyang Maud Pharmaceutical Technology Co., Ltd.
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024-23982345
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1020788318@qq.com
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China
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2251
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1798787-27-5, BIIB068Related Search:


  • BIIB068
  • BIIB-068
  • 1-Azetidinecarboxamide, 3-(1-methylethoxy)-N-[[2-methyl-4-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]phenyl]methyl]-
  • ADME,inhibit,FcγR,Autoimmune,Bruton tyrosine kinase,TNFα,BIIB 068,ROS,Inhibitor,reversible,Btk,anti-IgD,phosphorylation,BIIB068,anti-IgM,BIIB-068
  • N-[(2-methyl-4-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}phenyl)methyl]-3-(propan-2-yloxy)azetidine-1-carboxamide
  • 3-Isopropoxy-N-(2-methyl-4-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)benzyl)azetidine-1-carboxamide
  • BIIB068, 10 mM in DMSO
  • 1798787-27-5