ChemicalBook > CAS DataBase List > Boc-Val-Ala-PAB
Boc-Val-Ala-PAB
- Product Name
- Boc-Val-Ala-PAB
- CAS No.
- 1884577-99-4
- Chemical Name
- Boc-Val-Ala-PAB
- Synonyms
- Boc-Val-Ala-PAB;L-Alaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-;(S)-2-(Boc-amino)-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide;tert-butyl N-[(1S)-1-{[(1S)-1-[(4-(hydroxymethyl)phenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamate;tert-butyl N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate;tert-Butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
- CBNumber
- CB45864430
- Molecular Formula
- C20H31N3O5
- Formula Weight
- 393.48
- MOL File
- 1884577-99-4.mol
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Boc-Val-Ala-PAB Property
- Boiling point:
- 653.7±55.0 °C(Predicted)
- Density
- 1.166±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Solid
- pka
- 11.26±0.46(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Iris Biotech GmbH
- Product number
- ADC1040
- Product name
- Boc-Val-Ala-PAB
- Packaging
- 250mg
- Price
- $303.75
- Updated
- 2021/12/16
Iris Biotech GmbH
- Product number
- ADC1040
- Product name
- Boc-Val-Ala-PAB
- Packaging
- 1g
- Price
- $877.5
- Updated
- 2021/12/16
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Boc-Val-Ala-PAB Chemical Properties,Usage,Production
Description
Boc-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Boc-Val-Ala-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate (ADCs)[1][2].
References
[1] HP Wilson, et al. Pyrrolobenzodiazepines and conjugates thereof: World Intellectual Property Organization, WO2016037644. 2016-03-17.
[2] HP Wilson, et al. Preparation of pyrrolobenzodiazepine dimers and their conjugates with cell binding agents, especially pyrrolobenzodiazepine dimer drug linker antibody conjugates and their use for treating proliferative diseases, particularly cancer: World Intellectual Property Organization, WO2016038383. 2016-03-17
Boc-Val-Ala-PAB Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Boc-Val-Ala-PAB manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- Boc-Val-Ala-PAB 1884577-99-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >95.00%
- Supply Ability
- 1g
- Release date
- 2024-03-29