SC-99
- Product Name
- SC-99
- CAS No.
- 882290-02-0
- Chemical Name
- SC-99
- Synonyms
- SC-99;SC99, 10 mM in DMSO;N'-(3-Chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoacetohydrazonoyl cyanide;2-(2-(3-Chloro-4-fluorophenyl)hydrazono)-3-(4-chlorophenyl)-3-oxo-propanenitrile;Benzenepropanenitrile, 4-chloro-α-[2-(3-chloro-4-fluorophenyl)hydrazinylidene]-β-oxo-;orally,ERK,c-Src,SC 99,ATP-binding,phosphorylation,platelet,AKT,Janus kinase,activation,anti-myeloma,mTOR,anti-thrombotic,Inhibitor,myeloma,pocket,SC99,multiple,aggregation,STAT,OPM2,JAK,SC-99,Apoptosis,inhibit
- CBNumber
- CB45867552
- Molecular Formula
- C15H8Cl2FN3O
- Formula Weight
- 336.15
- MOL File
- 882290-02-0.mol
SC-99 Property
- Boiling point:
- 459.4±55.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- form
- Solid
- pka
- 4.83±0.10(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0088682
- Product name
- SC99
- Purity
- 99.07%
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0088682
- Product name
- SC99
- Purity
- 99.07%
- Packaging
- 10mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- CS-0088682
- Product name
- SC99
- Purity
- 99.07%
- Packaging
- 50mg
- Price
- $1150
- Updated
- 2021/12/16
- Product number
- CS-0088682
- Product name
- SC99
- Purity
- 99.07%
- Packaging
- 100mg
- Price
- $1750
- Updated
- 2021/12/16
- Product number
- A1359457
- Product name
- N'-(3-Chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoacetohydrazonoylcyanide
- Purity
- 98%
- Packaging
- 1mg
- Price
- $130
- Updated
- 2021/12/16
SC-99 Chemical Properties,Usage,Production
Uses
SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities[1][2][3].
in vivo
SC99 (30 mg/kg; orally; daily; for continuous 14 or 28 days) delays myeloma tumor growth in xenograft mice models[1].
SC99 (5, 10,15 mM, 15μL; ICV) produces an effective inhibitory effect on the phosphorylation of JAK2 and STAT3 in middle cerebral artery occlusion and reperfusion (MCAO/R) model (adult male SD rats; 250-300g). SC99 ameliorates neuronal apoptosis and degeneration, neurobehavioral deficits, inflammatory response and brain edema[3].
| Animal Model: | Nude mice with Human MM cells OPM2 or JJN3[1] |
| Dosage: | 30 mg/kg |
| Administration: | Orally; daily; for continuous 14 or 28 days |
| Result: | Delayed myeloma tumor growth in xenograft mice models and suppressed tumor growth more than 40% in 14 days in the OPM2 model. |
IC 50
STAT3; JAK2
References
[1] Zubin Zhang, et al. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Oncotarget. 2016 Feb 23;7(8):9296-308. DOI:10.18632/oncotarget.6974
[2] Zhuan Xu, et at. A novel STAT3 inhibitor negatively modulates platelet activation and aggregation. Acta Pharmacol Sin. 2017 May;38(5):651-659. DOI:10.1038/aps.2016.155
[3] Yiping Ding, et al. Effects of SC99 on cerebral ischemia-perfusion injury in rats: Selective modulation of microglia polarization to M2 phenotype via inhibiting JAK2-STAT3 pathway. Neurosci Res. 2019 May;142:58-68. DOI:10.1016/j.neures.2018.05.002
SC-99 Preparation Products And Raw materials
Raw materials
Preparation Products
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