d-Epigalbacin
- Product Name
- d-Epigalbacin
- CAS No.
- 84709-25-1
- Chemical Name
- d-Epigalbacin
- Synonyms
- epigalbacin;d-epigalacin;(-)-Zuonin A;d-Epigalbacin;1,3-Benzodioxole, 5,5'-[(2S,3R,4S,5S)-tetrahydro-3,4-dimethyl-2,5-furandiyl]bis-
- CBNumber
- CB45985179
- Molecular Formula
- C20H20O5
- Formula Weight
- 340.37
- MOL File
- 84709-25-1.mol
d-Epigalbacin Property
- Boiling point:
- 460.6±45.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8,11-12,19-20H,9-10H2,1-2H3/t11-,12+,19-,20-/m0/s1
- InChIKey
- QFUXQRHAJWXPGP-YLYZPZNOSA-N
- SMILES
- O1[C@H](C2=CC=C3OCOC3=C2)[C@@H](C)[C@@H](C)[C@H]1C1=CC=C2OCOC2=C1
N-Bromosuccinimide Price
- Product number
- CS-0119326
- Product name
- (-)-ZuoninA
- Purity
- 99.84%
- Packaging
- 1mg
- Price
- $200
- Updated
- 2021/12/16
d-Epigalbacin Chemical Properties,Usage,Production
Uses
(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].
Biological Activity
(-)-Zuonin A (D-Epigalbacin), a natural lignin, is a potent and selective inhibitor of JNKs with IC50 values of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.
in vitro
(?)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs.
(?)-zuonin A
target
| JNK1 1.7 μM (IC 50 ) | JNK2 2.9 μM (IC 50 ) | JNK3 1.74 μM (IC 50 ) |
IC 50
JNK1: 1.7 μM (IC50); JNK2: 2.9 μM (IC50); JNK3: 1.74 μM (IC50)
References
[1] Tamer S. Kaoud, et al. Manipulating JNK Signaling with (?)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873–1883. DOI:10.1021/cb300261e
d-Epigalbacin Preparation Products And Raw materials
Raw materials
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