JKE-1674

Product Name: JKE-1674
CAS No.: 2421119-60-8
Chemical Name: JKE-1674
Synonyms: JKE-1674;JKE-1674, 10 mM in DMSO;1,2-Propanedione, 1-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-3-nitro-, 2-oxime;(E)-1-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)-2-(hydroxyimino)-3-nitropropan-1-one;ML210,glutathione,Ferroptosis,JKE-1674,peroxidase,inhibit,JKE 1674,Glutathione Peroxidase,rescued,Inhibitor,JKE1674
CBNumber: CB46197997
Molecular Formula: C20H20Cl2N4O4
Formula Weight: 451.3
MOL File: 2421119-60-8.mol

More

Less

JKE-1674 Property

Boiling point:: 595.5±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO: soluble
form: A crystalline solid
pka: 6.67±0.58(Predicted)
color: Off-white to light yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

JKE-1674 Chemical Properties,Usage,Production

Biological Activity

JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210 .1 JKE-1674 reduces viability of LOX-IMVI cancer cells (EC50 = 0.03 μM) and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .

References

1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)

JKE-1674 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

JKE-1674 Suppliers

China 18 United States 4 Global 22

Beijing Biocreative Technology Co., Ltd.

Tel: 15522676233
Email: 3007606172@qq.com
Country: China
ProdList: 1248
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4589
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9804
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5960
Advantage: 55

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4999
Advantage: 55

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: zhouzz@univ-bio.com
Country: China
ProdList: 24998
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6830
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9266
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd

Tel: 13915962545
Email: 2881759498@qq.com
Country: China
ProdList: 8827
Advantage: 58

Tel
Email: sangon@qq.com
Country: CHINA
ProdList: 47239
Advantage: 58

LEAPCHEM CO., LTD.

Tel: +86-852-30606658
Email: market18@leapchem.com
Country: China
ProdList: 43340
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6579
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6681
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6705
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

2421119-60-8, JKE-1674Related Search:

JKE-1674

ML210,glutathione,Ferroptosis,JKE-1674,peroxidase,inhibit,JKE 1674,Glutathione Peroxidase,rescued,Inhibitor,JKE1674

1,2-Propanedione, 1-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-3-nitro-, 2-oxime

(E)-1-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)-2-(hydroxyimino)-3-nitropropan-1-one

JKE-1674, 10 mM in DMSO

2421119-60-8