Arachidonic Acid-d5

Arachidonic Acid-d5 Property

storage temp. 

Store at -20°C

solubility 

0.1 M Na2CO3: 1 mg/ml,DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml

form 

Liquid

color 

Colorless to light yellow

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

Arachidonic Acid-d5 Chemical Properties,Usage,Production

Uses

Arachidonic acid-d5 is the deuterium labeled Arachidonic acid. Arachidonic acid is an essential fatty acid and a major constituent of biomembranes.

Biological Activity

Arachidonic acid-d5 is intended for use as an internal standard for the quantification of arachidonic acid by GC- or LC-MS. Arachidonic acid is an essential fatty acid and a precursor for all prostaglandins, thromboxanes, and leukotrienes. Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways.1 Free arachidonic acid is a transient, critical substrate for the biosynthesis of eicosanoid second messengers. Receptor-stimulated release, metabolism, and re-uptake of free arachidonate are all important aspects of cell signaling and inflammation.2

References

1.Nixon, A.B., Greene, D.G., and Wykle, R.L.Comparison of acceptor and donor substrates in the CoA-independent transacylase reaction in human neutrophilsBiochim. Biophys. Acta.1300(3)187-196(1996) 2.Burgoyne, R.D., and Morgan, A.The control of free arachidonic acid levelsTrends Biochem. Sci.15(10)365-366(1990)