ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE
- Product Name
- ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE
- CAS No.
- 2528-00-9
- Chemical Name
- ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE
- Synonyms
- NSC 97518;BUTTPARK 96\50-29;ETHYL 5-(CHLOROMETHYL)-2-FUROATE;Ethyl 5-(chloromethyl)-2-furoate 95+%;Ethyl 5-(chloromethyl)-2-furancarboxy;Ethyl 5-(chloromethyl)-2-furoate, GC 95%;ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE;ethyl 5-(chloroMethyl)furan-2-carboxylate;5-(chloromethyl)-3-ethyl-2-furancarboxylate;Ethyl 5-Chloromethyl-2-furancarboxylate >
- CBNumber
- CB4664255
- Molecular Formula
- C8H9ClO3
- Formula Weight
- 188.61
- MOL File
- 2528-00-9.mol
ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE Property
- Boiling point:
- 115 °C0.015 mm Hg(lit.)
- Density
- 1.225 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.511(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Liquid
- Specific Gravity
- 1.225
- color
- Clear yellow
- CAS DataBase Reference
- 2528-00-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 433993
- Product name
- Ethyl 5-(chloromethyl)-2-furancarboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $144
- Updated
- 2023/01/07
- Product number
- C1494
- Product name
- Ethyl 5-Chloromethyl-2-furancarboxylate
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $100
- Updated
- 2024/03/01
- Product number
- E903753
- Product name
- Ethyl5-(Chloromethyl)furan-2-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-W005896
- Product name
- Ethyl5-(chloromethyl)furan-2-carboxylate
- Purity
- 99.80%
- Packaging
- 10g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- 084350
- Product name
- Ethyl 5-(Chloromethyl)-2-furoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
clear yellow liquid
Uses
Ethyl 5-(chloromethyl)-2-furancarboxylate may be employed for the synthesis of a series of novel sulfamide- and urea-based small-molecule antagonists of the protein-protein interaction IL-2/IL-2Rα. It may be employed as starting material for the synthesis of 5-hydroxymethylfuran-2-carboxylic acid.
Synthesis
105850-77-9
64-17-5
2528-00-9
Volatiles were removed by distillation under reduced pressure at room temperature and the crude product 5-(chloromethyl)-2-furancarbonyl chloride (4, 2.90 g) was dissolved in anhydrous ethanol (20 mL). The resulting clarified yellow solution was reacted at 50 °C with continuous stirring for 6 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator and the resulting residue was purified by column chromatography using dichloromethane/hexane (1:1 to 3:1 gradient) as eluent to afford the target product, ethyl 5-(chloromethyl)furan-2-carboxylate (5), as a colorless oil (2.390 g, 82% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) and 13C NMR (75 MHz, CDCl3): 1H NMR δ 7.06 (d, J = 3.5 Hz, 1H), 6.44 (d, J = 3.5 Hz, 1H), 4.55 (s, 2H), 4.31 (q, J = 7.1 Hz, 2H), 1.32 (t, J = 7.1 Hz, 3H); 13C NMR δ 158.35, 153.96, 145.02, 118.54, 111.37, 61.10, 36.68, 14.26.
References
[1] Green Chemistry, 2015, vol. 17, # 7, p. 3737 - 3739
[2] Patent: WO2016/191682, 2016, A1. Location in patent: Paragraph 0045
ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE manufacturers
- Product
- ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE 2528-00-9
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-25
- Product
- Ethyl 5-ChloroMethyl-2-furancarboxylate 2528-00-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-11
- Product
- ETHYL 5-(CHLOROMETHYL)-2-FURANCARBOXYLATE 2528-00-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-19