ChemicalBook > CAS DataBase List > 2-METHYL-[1,8]NAPHTHYRIDINE

2-METHYL-[1,8]NAPHTHYRIDINE

Uses

Product Name: 2-METHYL-[1,8]NAPHTHYRIDINE
CAS No.: 1569-16-0
Chemical Name: 2-METHYL-[1,8]NAPHTHYRIDINE
Synonyms: AKOS BBS-00006025;-1,8-naphthyridine;2-METHYL-[1,8]NAPHTHYRIDINE;1,8-Naphthyridine, 2-methyl-;2-Methyl-1,8-naphthyridine>2-Methylpyrido[2,3-b]pyridine;2-Methyl-1,8-diazanaphthalene;2-Methyl-1,8-naphthyridine,97%;2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-5,5-dimethylcyclohexane-1,3-dione
CBNumber: CB4672906
Molecular Formula: C9H8N2
Formula Weight: 144.17
MOL File: 1569-16-0.mol

Less

2-METHYL-[1,8]NAPHTHYRIDINE Property

Melting point:: 96-97°C
Boiling point:: 252.8±20.0 °C(Predicted)
Density: 1.141±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.02±0.30(Predicted)
color: Light yellow to Brown

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000831
Product name: 2-Methyl-[1,8]naphthyridine
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TCI Chemical

Product number: M2352
Product name: 2-Methyl-1,8-naphthyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $151
Updated: 2025/07/31

TRC

Product number: M330863
Product name: 2-Methyl-1,8-naphthyridine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 018154
Product name: 2-Methyl-[1,8]naphthyridine
Packaging: 1g
Price: $44
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-HS
Product name: 2-Methyl-[1,8]naphthyridine
Purity: 98%
Packaging: 1g
Price: $144
Updated: 2021/12/16

Less

2-METHYL-[1,8]NAPHTHYRIDINE Chemical Properties,Usage,Production

Uses

2-Methyl-[1,8]-naphthidine, also known as 2-methyl-1,8-naphthidine, is a pharmaceutical intermediate.

Synthesis

7521-41-7

67-64-1

1569-16-0

General procedure for the synthesis of 2-methyl-[1,8]-naphthyridine from 2-amino-3-pyridinecarboxaldehyde and acetone: 2-amino-3-pyridinecarboxaldehyde (11.10 g, 91 mmol), acetone (15.83 g, 272.9 mmol), and L-proline (11.40 g, 100.1 mmol) were dissolved in ethanol (120 mL), and the reaction was carried out under refluxing conditions with The reaction was stirred for 16 hours. After completion of the reaction, the reaction solution was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in dichloromethane (100 mL) and filtered to remove insoluble material. The filtrate was washed with deionized water (3 x 100 mL), the organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography with the eluent ethyl acetate:petroleum ether (1:10, v/v) to afford 2-methyl-[1,8]-naphthyridine as a white solid (13.0 g, 99% yield). Mass spectrum (ESI): m/z 145 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 10, p. 2679 - 2684
[2] Patent: WO2014/85284, 2014, A1. Location in patent: Paragraph 00227
[3] Organic and Biomolecular Chemistry, 2016, vol. 14, # 28, p. 6683 - 6686
[4] Patent: WO2018/132268, 2018, A1. Location in patent: Page/Page column 57
[5] Patent: WO2004/58761, 2004, A1. Location in patent: Page 32

2-METHYL-[1,8]NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-METHYL-[1,8]NAPHTHYRIDINE Suppliers

Americas 1 China 119 Europe 1 Germany 4 India 9 Japan 2 United Kingdom 4 United States 22 Global 162

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Sci General Material & Chemical Ltd

Tel: 021-58388037;21-58388037 13472507714
Email: 35177634@qq.com;1589045147@qq.com
Country: China
ProdList: 803
Advantage: 55

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2744
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Acesys Pharmatech

Tel: 18860950986
Email: tangmanman@zenjipharma.com
Country: China
ProdList: 1733
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

ShangHai D&B Biological Science and Technology Co.Ltd

Tel: 400-008-9730,021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3057
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9858
Advantage: 58

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Tcichem, Inc.

Tel: 13918644899
Fax: -
Email: tianchong009@hotmail.com
Country: China
ProdList: 1818
Advantage: 55

ShangHai Siyan Biological Technology Co., Ltd.

Tel: 021-50908862，442785678，326799392 18721037013
Fax: 021-50908862
Email: siyansales@126.com
Country: China
ProdList: 9627
Advantage: 58

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

Chengdu Xiaojia Technology Co., Ltd.

Tel: 15902830537
Email: zhanghao@happysyn.com
Country: China
ProdList: 3180
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10110
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Nanjing Klender Bio-Technology Co., Ltd.

Tel: 025-52343882 18112933882
Fax: 025-52343882
Email: sales@kldbio.com
Country: China
ProdList: 2019
Advantage: 55

Shanghai Kangman Biological Technology Co., Ltd.

Tel: 18800375331
Fax: 021-50908862
Email: kangmansales@163.com
Country: China
ProdList: 7570
Advantage: 55

Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
Fax: 0374-8348899
Email: 3224305243@qq.com
Country: China
ProdList: 2944
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

Nanijing m&m biotechnology Co. ,Ltd.

Tel: 025-87782433 18021532344
Fax: 025-87782433
Email: 1345332203@qq.com
Country: China
ProdList: 4134
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Nanjing NingFan Pharm-Tech CO. LTD.

Tel: 17368696818
Country: China
ProdList: 1984
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Yurlic Chemical S&T Co.Ltd.

Tel: 021-37285141 15618858630
Fax: 021-37285142
Email: yancf@yulibiotech.com
Country: China
ProdList: 170
Advantage: 58

Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
Email: 248775804@qq.com
Country: China
ProdList: 4995
Advantage: 58

Less

View Lastest Price from 2-METHYL-[1,8]NAPHTHYRIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Methyl-[1,8]-Naphthyridine 1569-16-0
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Career Henan Chemical Co

Product: 2-METHYL-[1,8]NAPHTHYRIDINE 1569-16-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 90%-99.9%
Supply Ability: 500kg
Release date: 2019-07-09

1569-16-0, 2-METHYL-[1,8]NAPHTHYRIDINERelated Search:

5,6,7,8-TETRAHYDRO-6-METHYL-1,6-NAPHTHYRIDIN-3-AMINE 3-ACETYL-2-METHYL-1,6-NAPHTHYRIDINE 2-[2-(2,3-Difluorophenyl)ethyl]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1,8-naphthyridine-1(4H)-acetamide 3-(CHLOROMETHYL)-6-(TRIFLUOROMETHYL)PYRIDINE 1-ETHYL-7-METHYL-1,8-NAPHTHYRIDINE-4-ONE-3-CARBOXYLIC ACID 7-CHLORO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid 5,7-DIMETHYL[1,8]NAPHTHYRIDIN-2-AMINE 5-CHLORO-2-METHYL-1,8-NAPHTHYRIDINE 2-METHYL-1,6-NAPHTHYRIDINE-3-CARBOXYLATE, ETHYL ESTER,2-METHYL-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ETHYL ESTER 3-Methyl-1,5-naphthyridine 4-Methyl-1,5-naphthyridine 2-METHYL-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID MONOHYDRATE 4-METHYL-1,8-NAPHTHYRIDINE 2-METHYL-1,5-NAPHTHYRIDINE 1,4-Dihydro-1-ethyl-4-oxo-7-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester 2-METHYL-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID 2-METHYL-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ACID

AKOS BBS-00006025

2-METHYL-[1,8]NAPHTHYRIDINE

2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-5,5-dimethylcyclohexane-1,3-dione

2-Methyl-1,8-naphthyridine&gt

1,8-Naphthyridine, 2-methyl-

2-Methyl-1,8-naphthyridine,97%

-1,8-naphthyridine

2-Methyl-1,8-diazanaphthalene

2-Methylpyrido[2,3-b]pyridine

1569-16-0

Heterocycle-Pyridine series