4-BROMO-7-CHLOROQUINOLINE
- Product Name
- 4-BROMO-7-CHLOROQUINOLINE
- CAS No.
- 98519-65-4
- Chemical Name
- 4-BROMO-7-CHLOROQUINOLINE
- Synonyms
- 4-BROMO-7-CHLOROQUINOLINE;7-chloro-4-bromo-quinoline;Quinoline, 4-bromo-7-chloro-;4-Bromo-7-chloro-1-azanaphthalene
- CBNumber
- CB4678584
- Molecular Formula
- C9H5BrClN
- Formula Weight
- 242.5
- MOL File
- 98519-65-4.mol
4-BROMO-7-CHLOROQUINOLINE Property
- Melting point:
- 101-103°C
- Boiling point:
- 331.3±22.0 °C(Predicted)
- Density
- 1.673
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, DMSO, Methanol
- pka
- 1.81±0.27(Predicted)
- form
- Solid
- color
- Tan
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BBO000238
- Product name
- 4-Bromo-7-chloroquinoline
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $330
- Updated
- 2025/07/31
- Product number
- B682550
- Product name
- 4-Bromo-7-chloroquinoline
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- B682550
- Product name
- 4-Bromo-7-chloroquinoline
- Packaging
- 10g
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- HCH0104703
- Product name
- 4-BROMO-7-CHLOROQUINOLINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1804.11
- Updated
- 2021/12/16
- Product number
- HCH0104703
- Product name
- 4-BROMO-7-CHLOROQUINOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $958.65
- Updated
- 2021/12/16
4-BROMO-7-CHLOROQUINOLINE Chemical Properties,Usage,Production
Chemical Properties
yellow powder
Uses
4-Bromo-7-chloroquinoline is a chemical reagent in the synthesis of autophagy antitumor inhibitors, as well as antifungal agents.
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 2232, 2007 DOI: 10.1021/jo062168u
Synthesis
86-98-6
98519-65-4
General procedure for the synthesis of 4-bromo-7-chloroquinoline from 4,7-dichloroquinoline: 4,7-dichloroquinoline (0.3315 g, 1.674 mmol) and propionitrile (3 mL) were added in a 20 mL microwave tube, followed by the slow addition of trimethylsilyl bromide (TMS-Br, 0.434 mL, 3.35 mmol) at room temperature. Precipitation generation was observed during the reaction. The reaction tube was sealed and placed in a 100 °C oil bath for 12 hours. After completion of the reaction, the system was cooled to room temperature. The crude reaction mixture was slowly poured into pre-cooled sodium hydroxide solution (1 N, 3 mL) and the reaction tube was rinsed with an appropriate amount of water. Subsequently, the aqueous layer was extracted with ether (3 x 5 mL). All ether layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 4-bromo-7-chloroquinoline (300 mg, 1.126 mmol, 67% yield) as a yellow solid. The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 8.70 (d, J = 4.6 Hz, 1H), 8.17 (d, J = 8.8 Hz, 1H), 8.14 (d, J = 2.0 Hz, 1H), 7.73 (d, J = 4.6 Hz, 1H), 7.63 (dd, J = 9.0, 2.0 Hz, 1H); liquid chromatography-mass spectrometry (LCMS, ESI) showed a molecular ion peak m/z of 241.9, which is consistent with the calculated value of C9H5BrClN.
References
[1] European Journal of Organic Chemistry, 2002, # 24, p. 4181 - 4184
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 3984,3986
[3] Patent: WO2017/59085, 2017, A1. Location in patent: Page/Page column 224; 225
4-BROMO-7-CHLOROQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-7-CHLOROQUINOLINE Suppliers
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 18030648795
- Fax
- 028-61777050
- sales@cdforestchem.com
- Country
- China
- ProdList
- 1998
- Advantage
- 58
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
- Tel
- +86-21-60341587
- Fax
- +86-21-61294319
- sales@topbiochem.com
- Country
- China
- ProdList
- 6175
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- +86-021-61654350
- Fax
- +86-021-61654350
- 1245958370@qq.com
- Country
- China
- ProdList
- 2982
- Advantage
- 50
- Tel
- 18662408853
- 2120408911@qq.com
- Country
- China
- ProdList
- 981
- Advantage
- 55
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60