DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER

Product Name: DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER
CAS No.: 1478-53-1
Chemical Name: DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER
Synonyms: diethyl(difluoromethyl)phosphonate;uoromethanephosphonate;Dimethyl(difluoromethyl)phosphonate;DIETHYL (DIFLUOROMETHANE)PHOSPHONATE;DIETHYL (DIFLUOROMETHYL)PHOSPHONATE 96%;DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER;1-[difluoromethyl(ethoxy)phosphoryl]oxyethane;P-DifluoroMethylphosphonic Acid Diethyl Ester;Phosphonic acid,P-(difluoromethyl)-, diethyl ester;Difluoromethylphosphonicaciddiethylester , Diethyl Difluoromethanephosphonate
CBNumber: CB4680440
Molecular Formula: C5H11F2O3P
Formula Weight: 188.11
MOL File: 1478-53-1.mol

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DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Property

Boiling point:: 96°C 15mm
Density: 1.193
refractive index: n20/D 1.388(lit.)
Flash point:: 113 °C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Oil
color: Clear Colourless
Specific Gravity: 1.193
InChI: InChI=1S/C5H11F2O3P/c1-3-9-11(8,5(6)7)10-4-2/h5H,3-4H2,1-2H3
InChIKey: VVFGLBKYBBUTRO-UHFFFAOYSA-N
SMILES: P(C(F)F)(=O)(OCC)OCC

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Safety

Hazard Codes: Xi
Risk Statements: 34
Safety Statements: 26-36/37/39
RIDADR: 3265
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 751596
Product name: Diethyl (difluoromethyl)phosphonate
Purity: 97%
Packaging: 5g
Price: $64.12
Updated: 2025/07/31

TRC

Product number: D444220
Product name: DiethylDifluoromethanephosphonate
Packaging: 200mg
Price: $270
Updated: 2021/12/16

Usbiological

Product number: 009460
Product name: Diethyl Difluoromethanephosphonate
Packaging: 1g
Price: $446
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6177-3-21
Product name: Diethyl (difluoromethyl)phosphonate
Packaging: 500mg
Price: $16
Updated: 2021/12/16

Matrix Scientific

Product number: 007431
Product name: Diethyl (difluoromethane)phosphonate
Purity: 98%
Packaging: 1g
Price: $21
Updated: 2021/12/16

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DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Colourless Liquid

Uses

Inhibitor of bacterial phosphotriesterases and an intermediate for the synthesis of 5’-diphosphate/5’-triphosphate mimics for transcriptase and glycerol kinase inhibition.

Synthesis Reference(s)

Tetrahedron Letters, 23, p. 2323, 1982 DOI: 10.1016/S0040-4039(00)87332-3

Synthesis

Diethyl Difluoromethylphosphonate is prepared by the reaction of sodium diethyl phosphite with Chlorodifluoromethane in hexane (49% yield) or in THF (77% yield) or generated in situ from diethyl bromodifluoromethylphosphonate and BuLi.

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER Suppliers

Canada 1 China 88 Germany 3 India 1 Switzerland 1 United Kingdom 5 United States 10 Global 109

SIGMA-RBI

Tel: --
Fax: --
Country: Switzerland
ProdList: 6896
Advantage: 91

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View Lastest Price from DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER 1478-53-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Henan Aochuang Chemical Co.,Ltd.

Product: DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER 1478-53-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

XINXIANG RUNYU MATERIAL CO., LTD.

Product: Difluoromethylphosphonic acid diethyl ester 1478-53-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100
Release date: 2024-04-08

1478-53-1, DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTERRelated Search:

DISPERSING AGENTS (DIETHOXYPHOSPHORYL)DIFLUOROMETHYLZINC BROMIDE METHYL-N-BOC-4[(DIETHOXY-PHOSPHORYL)-DIFLUORO]METHYL PHENYLALANINE (CHLOROCARBONYLDIFLUOROMETHYL)PHOSPHONIC ACID DIETHYL ESTER [DIFLUORO-(TETRAHYDRO-FURAN-3-YL)-METHYL]-PHOSPHONIC ACID DIETHYL ESTER DIISOPROPYL DIFLUOROMETHYLPHOSPHONATE Diethyl bromodifluoromethanephosphonate (DIETHOXYPHOSPHORYL)DIFLUOROACETIC ACID (CYCLOPENTYL-DIFLUORO-METHYL)-PHOSPHONIC ACID DIETHYL ESTER N-ALFA-FMOC-4-(PHOSPHONODIFLUOROMETHYL)-L-PHENYLALANINE DIBUTYL (DIFLUOROMETHANE)PHOSPHONATE (2-CYCLOHEXYL-1,1-DIFLUORO-ETHYL)-PHOSPHONIC ACID DIETHYL ESTER DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER

DIETHYL (DIFLUOROMETHANE)PHOSPHONATE

DIFLUOROMETHYLPHOSPHONIC ACID DIETHYL ESTER

diethyl(difluoromethyl)phosphonate

DIETHYL (DIFLUOROMETHYL)PHOSPHONATE 96%

P-DifluoroMethylphosphonic Acid Diethyl Ester

1-[difluoromethyl(ethoxy)phosphoryl]oxyethane

Phosphonic acid,P-(difluoromethyl)-, diethyl ester

uoromethanephosphonate

Difluoromethylphosphonicaciddiethylester , Diethyl Difluoromethanephosphonate

Dimethyl(difluoromethyl)phosphonate

1478-53-1

C5H11F2O3P

F2CHPOOC2H52

Inhibitors

Intermediates

Phosphorylating and Phosphitylating Agents