ChemicalBook > CAS DataBase List > MMP-8 INHIBITOR I
MMP-8 INHIBITOR I
- Product Name
- MMP-8 INHIBITOR I
- CAS No.
- 236403-25-1
- Chemical Name
- MMP-8 INHIBITOR I
- Synonyms
- MMP 8-I;MMP-8 INHIBITOR I;MMP-8 Inhibitor I (Matrix Metalloproteinase-8 Inhibitor I);(3R)-(+)-[2-(4-METHOXYBENZENESULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-3-HYDROXAMATE];3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-N-hydroxy-2-[(4-methoxyphenyl)sulfonyl]-, (3R)-
- CBNumber
- CB4710190
- Molecular Formula
- C17H18N2O5S
- Formula Weight
- 362.4
- MOL File
- Mol file
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MMP-8 INHIBITOR I Property
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Light Yellow
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21852
- Product name
- MMP-8 Inhibitor I
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $201
- Updated
- 2024/03/01
TRC
- Product number
- M425440
- Product name
- MMP8-I
- Packaging
- 100mg
- Price
- $1135
- Updated
- 2021/12/16
AK Scientific
- Product number
- 9999CR
- Product name
- Mmp-8inhibitori
- Packaging
- 1mg
- Price
- $322
- Updated
- 2021/12/16
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MMP-8 INHIBITOR I Chemical Properties,Usage,Production
Description
MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM. This inhibitor does not target the activities of other MMPs in vitro. MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization. Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.
Uses
MMP 8-I is a matrix metalloproteinase 8 inhibitor. Matrix metalloproteinases are involved with tight junction protein degradation in endothelial cells.
MMP-8 INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
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