METHYL 2-METHOXY-4-METHYLBENZOATE
- Product Name
- METHYL 2-METHOXY-4-METHYLBENZOATE
- CAS No.
- 81245-24-1
- Chemical Name
- METHYL 2-METHOXY-4-METHYLBENZOATE
- Synonyms
- Methyl o-methoxy-p-toluate;METHYL 2-METHOXY-4-METHYLBENZOATE;Methyl 4-Methyl-2-Methoxybenzoate;2-Methoxy-4-Methylbenzoic acid Methyl ester;Benzoic acid, 2-Methoxy-4-Methyl-, Methyl ester;2-methoxy-4-methyl-Benzoic acid methyl ester (9CI ACI);Benzoic acid, 2-methoxy-4-methyl-, methyl ester (9CI, ACI)
- CBNumber
- CB4712301
- Molecular Formula
- C10H12O3
- Formula Weight
- 180.2
- MOL File
- Mol file
METHYL 2-METHOXY-4-METHYLBENZOATE Property
- Melting point:
- 29℃
- Boiling point:
- 263-265℃
- Density
- 1.075±0.06 g/cm3(Predicted)
- refractive index
- 1.5230 (589.3 nm 18℃)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C10H12O3/c1-7-4-5-8(10(11)13-3)9(6-7)12-2/h4-6H,1-3H3
- InChIKey
- LHNVKRSDQCCHEK-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(C)C=C1OC
Safety
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M338578
- Product name
- Methyl2-Methoxy-4-methylbenzoate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W8578
- Product name
- Methyl2-methoxy-4-methylbenzoate
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
- Product number
- CS-M1058
- Product name
- methyl2-methoxy-4-methylbenzoate
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- W8578
- Product name
- Methyl2-methoxy-4-methylbenzoate
- Packaging
- 5g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- CS-M1058
- Product name
- methyl2-methoxy-4-methylbenzoate
- Purity
- >97.0%
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
METHYL 2-METHOXY-4-METHYLBENZOATE Chemical Properties,Usage,Production
Synthesis
50-85-1
77-78-1
81245-24-1
1. To a 1-liter three-necked round-bottomed flask (equipped with a dropping funnel, condenser, and magnetic stirring bar) were added 4-methylsalicylic acid (50 g, 0.33 mol), K2CO3 (91.1 g, 0.66 mol, 2 eq.), and anhydrous acetone. The mixture was heated to reflux while dimethyl sulfate (112.3 g, 0.891 mol, 2.7 eq.) was added dropwise. The reaction mixture was refluxed for about 14 hours (completion of the reaction was monitored by TLC). The inorganic salt was removed by filtration and the THF filtrate was evaporated under reduced pressure to give a yellow oil. 2. The residue was dissolved in a mixture of 400 mL of methanol and concentrated NH4OH (115 mL). Stir for 30 minutes at room temperature. The methanol was removed by distillation, the residue was diluted with water (500 ml) and the oily product was extracted with ether (3 x 300 ml). The organic extracts were combined, dried with sodium sulfate, and the ether was removed under reduced pressure to give pure methyl 2-methoxy-4-methylbenzoate (57 g, 96% yield) as a yellow oil. 3. To a dry 2-liter, three-necked, round-bottomed flask (equipped with an argon inlet, a thermometer, a magnetic stirring bar, and a septum) was added THF (220 ml) and diisopropylamine (54.6 ml, 0.39 mol, 1.2 eq.). The mixture was cooled to -50 °C and a solution of 2.5 M n-BuLi (156 mL, 0.39 mol, 1.2 eq.) was slowly added through the cannula. After stirring at -50 °C for 30 min, the resulting LDA solution was cooled to -78 °C, HMPA (67.8 mL, 0.39 mol, 1.2 eq.) was added, followed by a solution of methyl 2-methoxy-4-methylbenzoate (57 g, 0.32 mol) in THF (220 mL), keeping the temperature at -78 °C. The reaction mixture was stirred at -78 °C for an additional 2 h and then transferred to a flask containing 100 g of dry ice and THF (200 mL). After stirring at -78 °C for 30 min, the mixture was slowly warmed to room temperature and poured into water (1.5 liters). The organic layer was separated and the aqueous layer was further extracted with ether (3 x 1 liter). The aqueous layer was acidified with 10% H2SO4 (150 ml) and the reaction product was extracted with CH2Cl2 (3 x 1.5 liters). The organic extracts were combined, dried with anhydrous Na2SO4, the solvent was removed under reduced pressure, and the crude product was purified by fast chromatography (eluent: EtOAc:hexane 3:7) and recrystallized from CH2Cl2:hexane 1:1 to give pure methyl 4-carboxymethyl-2-methoxybenzoate (38.8 g, 54.7% yield). 4. Methyl 4-carboxymethyl-2-methoxybenzoate (12.7 g, 0.0567 mol) was dissolved in glacial acetic acid (100 mL) and bromine (3.2 mL, 0.0624 mol, 1.1 eq.) was added dropwise via a syringe, maintaining the internal temperature at room temperature. After stirring for 4 h, the AcOH was removed by evaporation and the orange oil was evaporated twice with toluene to give an orange solid. The substance was ground with CH2Cl2 and filtered to remove some of the precipitated product. The remaining product in the filtrate was concentrated on a silica gel column, eluting with EtOAc:hexane (6:4) containing 1% AcOH. Further purification by a second chromatography and recrystallization from EtOAc:hexane gave pure methyl 5-bromo-4-carboxymethyl-2-methoxybenzoate (9 g total, 52% yield) as a white solid.
References
[1] Patent: WO2004/108673, 2004, A2. Location in patent: Page 45-46
[2] Bioorganic and medicinal chemistry, 2002, vol. 10, # 9, p. 3013 - 3021
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2334 - 2356
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 19, p. 4987 - 4993
[5] Patent: WO2004/65367, 2004, A1. Location in patent: Page 152 - 153; 157
METHYL 2-METHOXY-4-METHYLBENZOATE Preparation Products And Raw materials
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View Lastest Price from METHYL 2-METHOXY-4-METHYLBENZOATE manufacturers
- Product
- METHYL 2-METHOXY-4-METHYLBENZOATE 81245-24-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- METHYL 2-METHOXY-4-METHYLBENZOATE 81245-24-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- METHYL 2-METHOXY-4-METHYLBENZOATE 81245-24-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20KG
- Release date
- 2018-08-14