ETHYL PHENYLCYANOACETATE Property

Melting point:

115-116 °C

Boiling point:

275 °C (lit.)

Density 

1.09 g/mL at 25 °C (lit.)

refractive index 

1.5033-1.5053

Flash point:

>110°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform, DMSO, Methanol (Slightly)

form 

Liquid

color 

Clear colorless to light yellow

BRN 

611232

CAS DataBase Reference

4553-07-5(CAS DataBase Reference)

Safety

Hazard Codes 

Xn

Risk Statements 

20/21-36/37/38-20/21/22

Safety Statements 

23-37/39-26

RIDADR 

UN3276

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29269095

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

ETHYL PHENYLCYANOACETATE Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

Ethyl phenylcyanoacetate?is a reagent used for the asymmetric synthesis of?(-)-manzacidin A.?It is also a useful reagent for C-C bond formation by conjugate additions with vinyl sulfones.

Definition

ChEBI: An alpha-substituted cyanoacetate ester that consists of ethyl cyanoacetate bearing an alpha-phenyl substituent.

Synthesis Reference(s)

Journal of the American Chemical Society, 64, p. 576, 1942 DOI: 10.1021/ja01255a033
Organic Syntheses, Coll. Vol. 4, p. 461, 1963
Synthesis, p. 67, 1983