4'-(TRIFLUOROMETHYL)PROPIOPHENONE
- Product Name
- 4'-(TRIFLUOROMETHYL)PROPIOPHENONE
- CAS No.
- 711-33-1
- Chemical Name
- 4'-(TRIFLUOROMETHYL)PROPIOPHENONE
- Synonyms
- p-trifluoromethylpropiophenone;4-(TRIFLUOROMETHYL)PROPIOPHENONE;4'-(trifluoromethyl)propiophenone;4'-(Trifluoromethyl)propiophenone 97%;4'-(Trifluoromethyl)propiophenone,97%;Ethyl 4-(trifluoromethyl)phenyl ketone;p-Trifluoromethylpropiophenone, min. 97%;1-[4-(Trifluoromethyl)phenyl]-1-propanone;1-(4-(trifluoromethyl)phenyl)propan-1-one;1-Propanone, 1-[4-(trifluoromethyl)phenyl]-
- CBNumber
- CB4723967
- Molecular Formula
- C10H9F3O
- Formula Weight
- 202.17
- MOL File
- 711-33-1.mol
4'-(TRIFLUOROMETHYL)PROPIOPHENONE Property
- Melting point:
- 36-39 °C(lit.)
- Boiling point:
- 216 °C(lit.)
- Density
- 1,973 g/cm3
- Flash point:
- 210 °F
- storage temp.
- Inert atmosphere,Room Temperature
- form
- fused solid
- color
- White/colourless
- BRN
- 1874014
- CAS DataBase Reference
- 711-33-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T4250
- Product name
- 1-[4-(Trifluoromethyl)phenyl]propan-1-one
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $90
- Updated
- 2025/07/31
- Product number
- T895640
- Product name
- 4''-(Trifluoromethyl)propiophenone
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 006493
- Product name
- 4'-(Trifluoromethyl)propiophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 2817-3-14
- Product name
- 4'-(Trifluoromethyl)propiophenone
- Purity
- 97%
- Packaging
- 5G
- Price
- $35
- Updated
- 2021/12/16
- Product number
- PC7766
- Product name
- 4'-(Trifluoromethyl)propiophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $47
- Updated
- 2021/12/16
4'-(TRIFLUOROMETHYL)PROPIOPHENONE Chemical Properties,Usage,Production
Chemical Properties
solid
Uses
4-(Trifluoromethyl)propiophenone is used as a reagent in the preparation of ketones and alcohols in organic synthesis. It is also used as a starting material for the synthesis of various compounds such as 4-(trifluoromethyl)phenylacetic acid, which is used as a building block in the synthesis of pharmaceuticals.
Synthesis
67081-98-5
711-33-1
General procedure for the synthesis of 4-(trifluoromethyl)propiophenone from 1-(4-trifluoromethylphenyl)-1-propanol: First, a solution of 1-(4-trifluoromethylphenyl)-1-propanol prepared in step 1 was mixed with 3.9 kg of tetrabutylammonium hydrogensulphate and 12.3 kg of sodium dihydrogen phosphate dihydrate and dissolved in 32 L of deionized water. Subsequently, the mixture was washed with 10 L of deionized water, and then 318 kg of a 12% aqueous sodium perchlorate solution was added to the mixture, followed by washing the reaction mixture with 35 L of deionized water. The resulting solution was allowed to stand for 30 minutes before the organic layer was separated and mixed with 358 L of deionized water and 18 kg of 38% hydrochloric acid and stirred for 5 minutes. The organic layer was separated and washed with deionized water to finally obtain 378 kg of 4-(trifluoromethyl)propiophenone from the organic layer (yield: 97.2%).
References
[1] Synthetic Communications, 1989, vol. 19, # 9-10, p. 1735 - 1744
[2] Patent: WO2006/112565, 2006, A1. Location in patent: Page/Page column 16-17
[3] Journal of Medicinal Chemistry, 1995, vol. 38, # 20, p. 3918 - 3932
[4] European Journal of Medicinal Chemistry, 1995, vol. 30, # 1, p. 85 - 94
[5] Journal of Organic Chemistry, 2003, vol. 68, # 4, p. 1594 - 1596
4'-(TRIFLUOROMETHYL)PROPIOPHENONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4'-(TRIFLUOROMETHYL)PROPIOPHENONE manufacturers
- Product
- 4'-(TRIFLUOROMETHYL)PROPIOPHENONE 711-33-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-07
- Product
- 4'-(TRIFLUOROMETHYL)PROPIOPHENONE 711-33-1
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-17
- Product
- 4'-(TRIFLUOROMETHYL)PROPIOPHENONE 711-33-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 200kgs
- Release date
- 2020-01-10