SNDX-5613

Product Name: SNDX-5613
CAS No.: 2169919-21-3
Chemical Name: SNDX-5613
Synonyms: SNDX-5613;Revumenib;SNDX-5613 SNDX5613;SNDX-5613, 10 mM in DMSO;acute,Leukemia,inhibit,lymphoblastic,Epigenetic Reader Domain,Inhibitor,AML,Menin,ALL,SNDX 5613,SNDX-5613,SNDX5613,MLL,myeloid;N-Ethyl-2-((4-(7-((trans-4-(ethylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)-5-fluoro-N-isopropylbenzamide;N-ethyl-2-((4-(7-(((1r,4r)-4-(ethylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)-5-fluoro-N-isopropylbenzamide;N-Ethyl-2-[[4-[7-[[trans-4-[(ethylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-5-fluoro-N-(1-methylethyl)benzamide;Benzamide, N-ethyl-2-[[4-[7-[[trans-4-[(ethylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-5-fluoro-N-(1-methylethyl)-
CBNumber: CB47244410
Molecular Formula: C32H47FN6O4S
Formula Weight: 630.82
MOL File: 2169919-21-3.mol

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SNDX-5613 Property

Boiling point:: 739.1±70.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
solubility: DMSO:30.0(Max Conc. mg/mL);47.56(Max Conc. mM)
pka: 11.10±0.40(Predicted)
form: Solid
color: White to off-white
InChIKey: FRVSRBKUQZKTOW-YOCNBXQISA-N
SMILES: C(N(CC)C(C)C)(=O)C1=CC(F)=CC=C1OC1=CN=CN=C1N1CC2(CCN(C[C@@H]3CC[C@@H](NS(CC)(=O)=O)CC3)CC2)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0120274
Product name: SNDX-5613
Purity: 99.62%
Packaging: 5mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0120274
Product name: SNDX-5613
Purity: 99.62%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0120274
Product name: SNDX-5613
Purity: 99.62%
Packaging: 25mg
Price: $1250
Updated: 2021/12/16

ChemScene

Product number: CS-0120274
Product name: SNDX-5613
Purity: 99.62%
Packaging: 50mg
Price: $1850
Updated: 2021/12/16

ChemScene

Product number: CS-0120274
Product name: SNDX-5613
Purity: 99.62%
Packaging: 100mg
Price: $2750
Updated: 2021/12/16

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SNDX-5613 Chemical Properties,Usage,Production

Uses

Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].

in vivo

Revumenib (SNDX-5613) shows in vivo plasma IC₅₀ of 53 nM. Revumenib treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts^[1].

References

[1] A drug, SNDX-5613, to treat acute leukemia with a KMT2A translocation or an NPM1 mutation that has come back (relapsed) or has not gotten better with treatment (refractory).

SNDX-5613 Preparation Products And Raw materials

Raw materials

Preparation Products

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SNDX-5613 Suppliers

China 83 United States 4 Global 87

NANJING WEDO PHARMATECH CO.,LTD.

Tel: 15189836218 15189836218;
Email: wedo-chem@huawe.com
Country: China
ProdList: 262
Advantage: 58

Taizhou Zhongzhi Biotechnology Co., Ltd

Tel: 13012344321
Email: 3995296515@qq.com
Country: China
ProdList: 9370
Advantage: 58

Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.

Tel: 13771642864
Fax: 1078336263
Email: snhuyu_2008@126.com
Country: China
ProdList: 1189
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2769
Advantage: 58

SINO High Goal Chemical Technology Co., Ltd.

Tel: 021-57646680 18306277365
Fax: 2469917557
Email: sunkai@chembiobanksh.com
Country: China
ProdList: 2039
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7777
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
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View Lastest Price from SNDX-5613 manufacturers

Wuhan Nutra Biotechnology Co.,Ltd

Product: SNDX-5613 2169919-21-3
Price: US $1.00/box
Min. Order: 1box
Purity: 98%
Supply Ability: 1
Release date: 2022-11-19

2169919-21-3, SNDX-5613Related Search:

SNS-062 PF-04929113 4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea

SNDX-5613

acute,Leukemia,inhibit,lymphoblastic,Epigenetic Reader Domain,Inhibitor,AML,Menin,ALL,SNDX 5613,SNDX-5613,SNDX5613,MLL,myeloid

Benzamide, N-ethyl-2-[[4-[7-[[trans-4-[(ethylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-5-fluoro-N-(1-methylethyl)-

SNDX-5613 SNDX5613

Revumenib

N-Ethyl-2-((4-(7-((trans-4-(ethylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)-5-fluoro-N-isopropylbenzamide

SNDX-5613, 10 mM in DMSO

N-ethyl-2-((4-(7-(((1r,4r)-4-(ethylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)-5-fluoro-N-isopropylbenzamide

N-Ethyl-2-[[4-[7-[[trans-4-[(ethylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-5-fluoro-N-(1-methylethyl)benzamide

2169919-21-3