ChemicalBook > CAS DataBase List > SNDX-5613
SNDX-5613
- Product Name
- SNDX-5613
- CAS No.
- 2169919-21-3
- Chemical Name
- SNDX-5613
- Synonyms
- SNDX-5613;Revumenib;SNDX-5613 SNDX5613;SNDX-5613, 10 mM in DMSO;acute,Leukemia,inhibit,lymphoblastic,Epigenetic Reader Domain,Inhibitor,AML,Menin,ALL,SNDX 5613,SNDX-5613,SNDX5613,MLL,myeloid;N-Ethyl-2-((4-(7-((trans-4-(ethylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)-5-fluoro-N-isopropylbenzamide;N-ethyl-2-((4-(7-(((1r,4r)-4-(ethylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)-5-fluoro-N-isopropylbenzamide;Benzamide, N-ethyl-2-[[4-[7-[[trans-4-[(ethylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-5-fluoro-N-(1-methylethyl)-
- CBNumber
- CB47244410
- Molecular Formula
- C32H47FN6O4S
- Formula Weight
- 630.82
- MOL File
- 2169919-21-3.mol
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SNDX-5613 Property
- Boiling point:
- 739.1±70.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
- solubility
- DMSO:30.0(Max Conc. mg/mL);47.56(Max Conc. mM)
- pka
- 11.10±0.40(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- FRVSRBKUQZKTOW-YOCNBXQISA-N
- SMILES
- C(N(CC)C(C)C)(=O)C1=CC(F)=CC=C1OC1=CN=CN=C1N1CC2(CCN(C[C@@H]3CC[C@@H](NS(CC)(=O)=O)CC3)CC2)C1
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0120274
- Product name
- SNDX-5613
- Purity
- 99.62%
- Packaging
- 5mg
- Price
- $500
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0120274
- Product name
- SNDX-5613
- Purity
- 99.62%
- Packaging
- 10mg
- Price
- $850
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0120274
- Product name
- SNDX-5613
- Purity
- 99.62%
- Packaging
- 25mg
- Price
- $1250
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0120274
- Product name
- SNDX-5613
- Purity
- 99.62%
- Packaging
- 50mg
- Price
- $1850
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0120274
- Product name
- SNDX-5613
- Purity
- 99.62%
- Packaging
- 100mg
- Price
- $2750
- Updated
- 2021/12/16
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SNDX-5613 Chemical Properties,Usage,Production
Uses
Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1].
in vivo
Revumenib (SNDX-5613) shows in vivo plasma IC50 of 53 nM. Revumenib treatment provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts[1].
References
[1] A drug, SNDX-5613, to treat acute leukemia with a KMT2A translocation or an NPM1 mutation that has come back (relapsed) or has not gotten better with treatment (refractory).
SNDX-5613 Preparation Products And Raw materials
Raw materials
Preparation Products
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SNDX-5613 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
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View Lastest Price from SNDX-5613 manufacturers
Wuhan Nutra Biotechnology Co.,Ltd
- Product
- SNDX-5613 2169919-21-3
- Price
- US $1.00/box
- Min. Order
- 1box
- Purity
- 98%
- Supply Ability
- 1
- Release date
- 2022-11-19
2169919-21-3, SNDX-5613Related Search:
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PF-04929113
4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide
N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride
N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea