N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine

Product Name: N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
CAS No.: 1071098-42-4
Chemical Name: N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine
Synonyms: AZA1, 10 mM in DMSO;AZA1（Rac1/Cdc42-IN-1）;Cdc42/Rac1 Dual Inhibitor, AZA1;AZA1 (Synonyms: Rac1/Cdc42-IN-1);N2,N?-bis(2-Methyl-1H-indol-5-yl)pyrimidine-2,4-diamine;N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine;2-N,4-N-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, N2,N4-bis(2-methyl-1H-indol-5-yl)-
CBNumber: CB47247466
Molecular Formula: C22H20N6
Formula Weight: 368.43
MOL File: 1071098-42-4.mol

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N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine Property

Boiling point:: 711.0±70.0 °C(Predicted)
Density: 1.388±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 100mg/mL
form: Solid
pka: 17.48±0.30(Predicted)
color: Light brown to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.30152
Product name: Cdc42/Rac1 Dual Inhibitor, AZA1
Packaging: 10 mg
Price: $220
Updated: 2025/07/31

ChemScene

Product number: CS-0128934
Product name: AZA1
Purity: 98.65%
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0128934
Product name: AZA1
Purity: 98.65%
Packaging: 10mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0128934
Product name: AZA1
Purity: 98.65%
Packaging: 50mg
Price: $1350
Updated: 2021/12/16

ChemScene

Product number: CS-0128934
Product name: AZA1
Purity: 98.65%
Packaging: 100mg
Price: $1950
Updated: 2021/12/16

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N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine Chemical Properties,Usage,Production

Description

AZA1 is a Rac1/Cdc42 GTPase-specific inhibitor which suppresses prostate cancer.

Uses

AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion[1][2].

in vivo

AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) is potent in suppressing human 22Rv1 xenograft growth in mice and improving survival^[1].

Animal Model:	5 week-old athymic nu/nu (nude) mice (bearing 22Rv1 prostate cancer cell xenografts)^[1]
Dosage:	100 μg in 100 μl 30% DMSO
Administration:	I.p.; daily for 2 weeks
Result:	The suppressive effect of AZA1 on tumor growth was significant.

References

[1] Zins K, et al. A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice. PLoS One. 2013;8(9):e74924. Published 2013 Sep 11. DOI:10.1371/journal.pone.0074924
[2] Suzuki O, et al. Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family. Int J Oncol. 2015;47(6):2091‐2099. DOI:10.3892/ijo.2015.3211

N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine Preparation Products And Raw materials

Raw materials

Preparation Products

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N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine Suppliers

China 34 United States 2 Global 36

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1071098-42-4, N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamineRelated Search:

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N2,N4-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine

N2,N?-bis(2-Methyl-1H-indol-5-yl)pyrimidine-2,4-diamine

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2-N,4-N-bis(2-methyl-1H-indol-5-yl)pyrimidine-2,4-diamine

AZA1, 10 mM in DMSO

Cdc42/Rac1 Dual Inhibitor, AZA1

AZA1 (Synonyms: Rac1/Cdc42-IN-1)

AZA1（Rac1/Cdc42-IN-1）

1071098-42-4