ChemicalBook > CAS DataBase List > 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE

Product Name
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
CAS No.
67469-57-2
Chemical Name
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
Synonyms
CS-1338;GBR-12783;GBR 12921;GBR127832HCl;GBR 12783 DIHYDROCHLORIDE;1-(2-(Benzhydryloxy)ethyl)-4-cinnamylpiperazine;1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine;Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-;1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)piperazine;Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-
CBNumber
CB4726281
Molecular Formula
C28H32N2O
Formula Weight
412.57
MOL File
67469-57-2.mol
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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Property

Melting point:
>200°C (dec.)
Boiling point:
551℃
Density 
1.085
Flash point:
148℃
storage temp. 
Desiccate at -20°C
solubility 
Methanol (Slightly), Water (Slightly, Heated)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
0513
Product name
GBR12783dihydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$139
Updated
2021/12/16
Tocris
Product number
0513
Product name
GBR12783dihydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$575
Updated
2021/12/16
TRC
Product number
G268008
Product name
GBR12783
Packaging
10mg
Price
$95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0001781
Product name
1-(2-(DIPHENYLMETHOXY)ETHYL)-4-(3-PHENYL-2-PROPENYL)PIPERAZINE
Purity
95.00%
Packaging
1G
Price
$599.55
Updated
2021/12/16
DC Chemicals
Product number
DC9213
Product name
GBR12783
Purity
>98%
Packaging
100mg
Price
$300
Updated
2021/12/16
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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

GBR 12783 is a very potent and selective inhibitor of dopamine uptake.

Definition

ChEBI: 1-[2-(diphenylmethyl)oxyethyl]-4-(3-phenylprop-2-enyl)piperazine is a diarylmethane.

Biological Activity

A very potent and selective inhibitor of dopamine uptake (IC 50 for inhibition of [ 3 H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).

in vivo

GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].

Animal Model:Male Sprague-Dawley rats (180-200 g)[1]
Dosage:10 mg/kg
Administration: Intraperitoneal injection; for 100 minutes
Result:For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE Suppliers

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67469-57-2, 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDERelated Search:

1-ALLYL-4-(2-HYDROXYETHYL)-PIPERAZINE 1-CINNAMYLPIPERAZINE DIHYDROCHLORIDE CINNAMYL PIEPRAZINE HYDROCHLORIDE Diphenhydramine Hydrochloride TRANS-1-CINNAMYLPIPERAZINE Diphenhydramine 1-(2-ETHOXYETHYL)PIPERAZINE 2-(DIPHENYLMETHOXY)-N-METHYLETHYLAMINE 1-(2-BENZYLOXY-ETHYL)-PIPERAZINE 1-(2-(BIS-(4-FLUOROPHENYL)METHOXY)ETHYL)-4-(3-PHENYL-2-PROPENYL)PIPERAZINE DIHYDROCHLORIDE 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE

  • Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-
  • 1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
  • GBR 12783 DIHYDROCHLORIDE
  • GBR127832HCl
  • GBR 12921
  • 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine
  • GBR-12783
  • 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)piperazine
  • 1-[2-(diphenylMethoxy)ethyl]-4-(3-phenylprop-2-en-1-yl)piperazine dihydrochloride
  • CS-1338
  • 1-(2-(Benzhydryloxy)ethyl)-4-cinnamylpiperazine
  • Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-
  • 67469-57-2
  • C28H32N2O2HCl
  • Dopamine receptor